Category: 105942-08-3

Synthetic Route of C7H3BrFNIn 2021 ,《Redox-Neutral Cross-Coupling Amination with Weak N-Nucleophiles: Arylation of Anilines, Sulfonamides, Sulfoximines, Carbamates and Imines via Nickelaelectrocatalysis》 was published in JACS Au. The article was written by Zhu, Chen; Kale, Ajit Prabhakar; Yue, Huifeng; Rueping, Magnus. The article contains the following contents:

A nickel-catalyzed cross-coupling amination of aryl halides/aryl tosylates with weak nitrogen nucleophiles including anilines, sulfonamides, sulfoximines, carbamates and imines via concerted paired electrolysis was described to provide substituted amines Ar1NHAr2 [Ar1 = 4-MeC6H4, 4-NCC6H4, 4-tBuC6H4, etc.; Ar2 = Ph, 2-naphthyl, 4-MeC6H4, etc.] and aryl sulfonamides Ar3NRSO2R1 [Ar3 = 2-MeC6H4, 4-NCC6H4, 4-tBuC6H4, etc.; R = H, Me R1 = Me, Bn, 4-MeC6H4, etc.]. Notably, electron-deficient anilines and sulfonamides were also suitable substrates. Interestingly, when benzophenone imine was applied in the arylation, the product selectivity toward the formation of amine and imine product could be addressed by a base switch. In addition, the a.c. mode could be successfully applied. DFT calculations supported a facilitated reductive elimination pathway. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Synthetic Route of C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Synthetic Route of C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Synthesis of PI3K inhibitor GDC-0077 via a stereocontrolled N-arylation of α-amino acids》 were Han, Chong; Kelly, Sean M.; Cravillion, Theresa; Savage, Scott J.; Nguyen, Tina; Gosselin, Francis. And the article was published in Tetrahedron in 2019. Category: nitriles-buliding-blocks The author mentioned the following in the article:

An efficient synthesis of PI3K inhibitor GDC-0077, featuring two consecutive Cu-catalyzed C-N coupling reactions, is reported. The described synthetic route involves a chemoselective Ullmann-type coupling of a chiral difluoromethyl-substituted oxazolidinone, a Cu-catalyzed N-arylation of L-alanine with high stereochem. integrity, and a high-yielding final amide bond formation step to produce GDC-0077 in >99.5 area % HPLC purity. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Category: nitriles-buliding-blocks)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Category: nitriles-buliding-blocks It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Regioregularity and Electron Deficiency Control of Unsymmetric Diketopyrrolopyrrole Copolymers for Organic Photovoltaics》 were Aoshima, Kenta; Nomura, Mayuka; Saeki, Akinori. And the article was published in ACS Omega in 2019. Formula: C7H3BrFN The author mentioned the following in the article:

Manipulating the electron deficiency and controlling the regioregularity of π-conjugated polymers are important for the fine-tuning of their electronic and electrochem. properties to make them suitable for an organic solar cell. Here, we report such a mol. design of unsym. diketopyrrolopyrrole (DPP) based copolymers with different aromatic side units of either thiophene (Th), pyridine (Py), or fluorobenzene (FBz). The unsym. electron acceptors of Th-DPP-Py and Th-DPP-FBz were polymerized with the electron donor of two-dimensional benzobisthiophene (BDT-Th), affording two regiorandom DPP copolymers. They exhibited contrasting MO levels and bulk heterojunction morphol. in methanofullerene-blended films, leading to power conversion efficiencies of 3.75 and 0.18%, resp. We further synthesized a regioregular DPP copolymer via sandwiching the centrosym. BDT-Th unit by two Th-DPP-Py units in an axisym. manner. The extensive characterization through morphol. observation, X-ray diffraction, and space-charge-limited current mobilities highlight the case-dependent pos./neg. effects of regioregularity and electron deficiency control. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Formula: C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Formula: C7H3BrFN It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Palladium Nanoparticles Immobilized on Schiff Base-Functionalized Graphene-Oxide: Application in Carbon-Carbon Cross-Coupling Reactions》 were Parmanand; Kumari, Shweta; Mittal, Ayushi; Kumar, Anoop; Krishna; Sharma, Sunil K.. And the article was published in ChemistrySelect in 2019. Reference of 4-Bromo-2-fluorobenzonitrile The author mentioned the following in the article:

Palladium nanoparticles immobilized on Schiff base-functionalized graphene-oxide (GO-Pd) was synthesized and characterized by FT-IR, Raman, PXRD, UV-Visible, TGA, XPS, FE-SEM, TEM, EDAX, Elemental mapping, BET, AAS and ICP MS anal. The GO-Pd showed promising catalytic activity for the Suzuki-Miyaura, Hiyama and Heck-Mizoroki coupling reactions with higher yields (up to 95%). The GO-Pd could be easily filtered out from the reaction mixture and reused up to six times without significant loss of catalytic activity. All of the synthetic products obtained were fully characterized from their spectral data. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Reference of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Reference of 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2018,Zhang, Xin; Wu, Ge; Gao, Wenxia; Ding, Jinchang; Huang, Xiaobo; Liu, Miaochang; Wu, Huayue published 《Synergistic Photo-Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides with Molecular Oxygen》.Organic Letters published the findings.COA of Formula: C7H3BrFN The information in the text is summarized as follows:

Photoredox-mediated copper-catalyzed hydroxylation of (hetero)aryl halides (including chlorides, bromides and iodides) with O2 at room temperature has been developed. Preliminary mechanistic studies indicate no arylcopper intermediate and that aryl radicals are involved in this procedure. 18O-labeling experiments confirm the hydroxyl oxygen atom originated from mol. oxygen. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3COA of Formula: C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.COA of Formula: C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2018,Soft Matter included an article by Pocock, Emily E.; Mandle, Richard J.; Goodby, John W.. Name: 4-Bromo-2-fluorobenzonitrile. The article was titled 《Molecular shape as a means to control the incidence of the nanostructured twist bend phase》. The information in the text is summarized as follows:

Eleven novel materials I [R = 4-(4-CNC6H4)C6H4, 4-(3,4-di-FC6H4)C6H4, 4-(4-F5SC6H4)C6H4, etc.] with all found to exhibited the twist-bend phase and a linear relationship between TN-I and TTB-N were prepared and studied. A computational study of the conformational landscape revealed the octamethyleneoxy spacer to had a broader distribution of bend-angles than the nonamethylene equivalent, leading to reductions in the thermal stability of the TB phase. This result indicates that a tight distribution of bend-angles should stabilize the TB phase and lead to direct TB-Iso phase transitions, and conversely a broader distribution should destabilize the TB phase which may allowed new states of matter that were occluded by the incidence of this phase to be revealed. In the part of experimental materials, we found many familiar compounds, such as 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Name: 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Name: 4-Bromo-2-fluorobenzonitrile It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

The author of 《Electrochemical Reductive Smiles Rearrangement for C-N Bond Formation》 were Chang, Xihao; Zhang, Qinglin; Guo, Chang. And the article was published in Organic Letters in 2019. Safety of 4-Bromo-2-fluorobenzonitrile The author mentioned the following in the article:

A conceptually new and synthetically valuable radical Smiles rearrangement reaction is reported under undivided electrolytic conditions. This protocol employs an entirely new strategy for the electrochem. radical Smiles rearrangement. Remarkably, an amidyl radical generated from the cleavage of the N-O bond under reductive electrolytic conditions plays a crucial role in this transformation. Various hydroxylamine derivatives bearing different substituents are suitable in this electrochem. transformation, furnishing the corresponding amides in up to 86% yield. In the part of experimental materials, we found many familiar compounds, such as 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Safety of 4-Bromo-2-fluorobenzonitrile)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Safety of 4-Bromo-2-fluorobenzonitrile 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Discovery and characterization of a novel perylenephotoreductant for the activation of aryl halides》 was written by Li, Min; Li, Jia; Guo, Baodang; Liu, Xuanzhong; Yuan, Zhenbo; Wu, Yawen; Yin, Huimin; Huang, Shuping; Zhang, Yan; Rao, Yijian. Related Products of 105942-08-3 And the article was included in Journal of Catalysis in 2021. The article conveys some information:

To develop a photocatalyst with catalytical activity for substrates with low reactivities is always highly desired. Herein, based on the principle of structure-property relationships, we rationally designed the natural product cercosporin, the naturally occurring perylenequinonoid pigment, to develop a novel organic perylenephotoreductant, hexacetyl reduced cercosporin (HARCP), through structural manipulation. Compared with cercosporin, HARCP shows prominent electrochem. and photophys. characteristics with greatly improved photoreductive activity, fluorescence lifetime and fluorescence quantum yield. These properties allowed HARCP as a powerful photoreductant to efficiently realize a series of benchmark reactions, including photoreduction, alkoxylation and hydroxylation to construct C-H and C-O bonds using aryl halides as substrates under mild conditions, all of which have never been achieved by the same photocatalyst. Thus, this study well supports the notion that the principle between structural manipulation and photocatalytic activity is of great significance to design customized photocatalysts for photoredox chem. The results came from multiple reactions, including the reaction of 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Related Products of 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Related Products of 105942-08-3 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

《Accessing Aliphatic Amines in C-C Cross-Couplings by Visible Light/Nickel Dual Catalysis》 was written by Dong, Weizhe; Badir, Shorouk O.; Zhang, Xuange; Molander, Gary A.. Recommanded Product: 105942-08-3This research focused ontrimethylsilylmethanamine aryl bromide nickel catalyst regioselective aminoalkylation; aryl methanamine preparation. The article conveys some information:

A general aminoalkylation of aryl halides were developed, overcoming intolerance of free amines in nickel-mediated C-C coupling. This transformation features broad functional group tolerance and high efficiency. Taking advantage of the fast desilylation of α-silylamines upon single-electron transfer (SET) facilitated by carbonate, α-amino radicals were generated regioselectively, which then engage in nickel-mediated C-C coupling. The reaction displays high chemoselectivity for C-C over C-N bond formation. Highly functionalized pharmacophores and peptides were also amenable. In the part of experimental materials, we found many familiar compounds, such as 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Recommanded Product: 105942-08-3)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a OLED intermediate, Pharmaceutical, electronic and chemical intermediate.Recommanded Product: 105942-08-3 It is used in the synthesis of heterocycles and liquid crystals.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In 2022,Wang, Jianhua; Li, Xiaoxun published an article in Chemical Science. The title of the article was 《Asymmetric β-arylation of cyclopropanols enabled by photoredox and nickel dual catalysis》.Synthetic Route of C7H3BrFN The author mentioned the following in the article:

The enantioselective functionalization and transformation of readily available cyclopropyl compounds are synthetically appealing yet challenging topics in organic synthesis. Here authors report an asym. β-arylation of cyclopropanols with aryl bromides enabled by photoredox and nickel dual catalysis. This dual catalytic transformation features a broad substrate scope and good functional group tolerance at room temperature, providing facile access to a wide array of enantioenriched β-aryl ketones bearing a primary alc. moiety in good yields with satisfactory enantioselectivities (39 examples, up to 83% yield and 90% ee). The synthetic value of this protocol was illustrated by the concise asym. construction of natural product calyxolane B analogs. In the experiment, the researchers used 4-Bromo-2-fluorobenzonitrile(cas: 105942-08-3Synthetic Route of C7H3BrFN)

4-Bromo-2-fluorobenzonitrile(cas:105942-08-3) is used as a reagent in the synthesis of picolinamide derivatives as a novel class of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.Synthetic Route of C7H3BrFN 4-Bromo-2-fluorobenzonitrile is also used in the preparation of fluorinated CB2 receptor agonists for PET imaging.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts