Category: 105-34-0

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. COA of Formula: C4H5NO2.

Tasqeeruddin, Syed;Asiri, Yahya I.;Shaheen, Syeda research published 《 NH₄Cl/Zn powder: An efficient, chemoselective reducing catalyst for the microwave-assisted synthesis of 2,3-disubstituted quinolines via tandem Knoevenagel condensation》, the research content is summarized as follows. An efficient, a hitherto unreported, sustainable, and environmentally friendly microwave-assisted synthesis of 2,3-disubstituted quinolines by reductive cyclization of 2-nitrobenzaldehydes and various active methylene compounds via tandem Knoevenagel condensation promoted by an efficient eco-friendly, chemoselective reducing catalyst ammonium chloride (NH₄Cl) and zinc powder was developed. This present methodol. is a mild, green, efficient, and environmentally benign process as it eliminates the harsh reaction conditions, non-volatile solvents, relatively expensive reagents, high catalyst loading, and also provides a number of other benefits like fast synthesis, simple reaction set-up, and good to the excellent yield of the products.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., COA of Formula: C4H5NO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate.The prefix cyano- is used interchangeably with the term nitrile in literature. SDS of cas: 105-34-0.

Trost, Barry M.;Jiao, Zhiwei;Liu, Ying;Min, Chang;Hung, Chao-I. Joey research published 《 Palladium-Catalyzed Enantioselective Cycloadditions of Aliphatic 1,4-Dipoles: Access to Chiral Cyclohexanes and Spiro [2.4] heptanes》, the research content is summarized as follows. Design and exploration of new intermediates for chemo-, regio-, and stereoselective cycloadditions remain a formidable challenge in modern organic synthesis. Compared to the well-developed 1,3-dipolar cycloadditions, Pd-catalyzed 1,4-dipolar cycloadditions are generally limited to specialized substrates due to the inherent nature of the thermodynamically driven intramol. transformations and undesired isomerizations. Herein, we demonstrate the use of ligated palladium catalysts to control and modulate the intermol. reactivity of aliphatic 1,4-dipoles, enabling two distinctive cycloaddition pathways with a broad scope of acceptors. This atom-economic process also features an eco-friendly in situ deprotonation strategy to generate the corresponding active palladium-mediated dipoles. Overall, a diverse array of chiral 6-membered rings and spiro [2.4] heptanes were prepared in high yield and selectivity. In addition, an unexpected property of cyano-stabilized carbanions was discovered and investigated, which can be useful in designing and predicting future transformations.

SDS of cas: 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Category: nitriles-buliding-blocks.

Sergeev, Pavel G.;Khrustalev, Victor N.;Nenajdenko, Valentine G. research published 《 Synthesis of Pyridazin-3(2H)-one Derivatives by the Reaction of CH-Acids with Dichlorodiazadienes》, the research content is summarized as follows. The reactions of 4,4-dichloro-1,2-diazabuta-1,3-dienes with di-Me malonate, cyanoacetic esters and Et acetoacetate provided straightforward access to highly functionalized pyridazine derivatives The approach was found to be very general for the highly efficient synthesis of various pyridazine derivatives , e.g., I, which can be isolated in moderate to excellent yields. The possibility of their subsequent functionalization was demonstrated. Moreover, the absorption characteristics in the UV/Vis-range and luminescence were studied for all synthesized compounds

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. SDS of cas: 105-34-0.

Shang, Zhi-Hao;Zhang, Zhen-Xiao;Weng, Wei-Zhao;Wang, Yu-Fei;Cheng, Tian-Wei;Zhang, Qiu-Yi;Song, Li-Qun;Shao, Tian-Qi;Liu, Kai-Xuan;Zhu, Yan-Ping research published 《 A Metal- and Azide-free Oxidative Coupling Reaction for the Synthesis of [1,2,3]Triazolo[1,5-a]quinolines and their Application to Construct C-C and C-P Bonds, 2-Cyclopropylquinolines and Imidazo[1,5-a]quinolines》, the research content is summarized as follows. An iodine-promoted one-pot cascade oxidative annulation reaction was developed for the synthesis of [1,2,3]triazolo[1,5-a]quinolines I [R = H, 7-F, 8-Cl, etc.] from Me azaarenes and N-tosylhydrazines. The reaction has a broad substrate scope and could be easily scaled up to gram-scale. 1,2,3-Triazoles were an important skeletal structure for the construction of C-C and C-P bonds, 2-cyclopropylquinolines and imidazo[1,5-a]quinolines, for which different synthetic applications were explored.

SDS of cas: 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate.The prefix cyano- is used interchangeably with the term nitrile in literature. Quality Control of 105-34-0.

Shanmugam, Kotteswaran;Sundaramoorthy, Kannadhasan;Perumalsamy, Ramasamy research published 《 The novel approach of stability aspect in organic oligoene dye for dye-sensitized solar cell applications》, the research content is summarized as follows. The phenyl-conjugated oligoene dye 2-cyano3-(4-diphenylaminophenyl)prop-2-enoic acid (SKS) was synthesized by chem. method, and its structure was confirmed by ¹H NMR and ¹³C NMR anal. Solar cell was made using TiO₂ (P-25) as photoanode, synthesized oligoene SKS dye as sensitizer, I^–/I^3- as electrolyte, and platinum as counter electrode. The overall power conversion efficiency of SKS dye based solar cell was 1.76%. The functional groups were identified from the FTIR spectrum. The optical, electrochem., and thermal properties were analyzed. The photostability of SKS dye was analyzed before and after various light irradiation by UV-Vis NIR absorption spectrum.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Quality Control of 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Category: nitriles-buliding-blocks.

Sharma, Neha;Kumar, Sunil;Battula, Venugopala R.;Kumari, Anu;Giri, Arkaprabha;Patra, Abhijit;Kailasam, Kamalakannan research published 《 A Tailored Heptazine-Based Porous Polymeric Network as a Versatile Heterogeneous (Photo)catalyst》, the research content is summarized as follows. A heptazine-based microporous polymeric network, HMP-TAPA was synthesized by direct coupling of trichloroheptazine and tris(4-aminophenyl)amine (TAPA). A high surface area of 424 m²/g was achieved, which is the highest surface area among heptazine-based polymeric networks (HMPs). The tailored electron-donor and -acceptor units in HMP-TAPA give broad visible-light absorption. HMP-TAPA was employed as metal-free photocatalyst for oxidative coupling of amines to imines under visible light irradiation with 98 % selectivity. Furthermore, the surface basicity of HMP-TAPA was used to achieve metal-free heterogeneous base catalysis for Knoevenagel condensation under base-free conditions with >99 % conversion. In addition, HMP-TAPA showed extreme robustness over a wide pH range (1-14). The versatility and flexibility of the current material design is beneficial for understanding its photoactivity and surface basicity so as to design dual active (photo)catalyst materials for specific applications.

Category: nitriles-buliding-blocks, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Recommanded Product: Methyl 2-cyanoacetate.

Shaw, Ranjay;Pratap, Ramendra research published 《 A Green and Base-Free Arylation of Thiomethylated 2-pyranones and Ketene Dithioacetals via Liebeskind-Srogl Coupling in Water》, the research content is summarized as follows. A green and base-free desulfitative coupling of different thioethers I (X = CN, COOMe; Ar¹ = 4-methoxyphenyl, 4-fluorophenyl, thiophen-2-yl;) with aryl boronic acids Ar²B(OH)₂ (Ar² = Ph, naphthalen-2-yl, thiophen-3-yl, etc.) to botain II in water was described. Various thiomethylated 2H-pyran-2-ones I (X = CN, COOMe), 2-oxobenzo[h]chromones II and α-aroyl ketene-dithioacetals R²CH(O)CH=C(SCH₃)₂ (R² = Ph, naphthalen-2-yl, thiophen-2-yl, etc.) were used as substrate to obtained arylated product I, II in very good to excellent yield. Further utility of reaction was carried out by a one-pot arylation followed by amination of α-aroyl ketene dithioacetals for the synthesis of 1-(4-bromophenyl)-3-morpholino-3-phenylprop-2-en-1-one and diarylazoles III (R³ = Ph, 4-methoxyphenyl, furan-2-yl, etc.; R⁴ = Ph, thiophen-3-yl, etc.; X = NH, O). The structure of isolated product 2-Oxo-4-phenyl-5,6-dihydro-2H-benzo[h]chromene-3-carbonitrile and (Z)-1-(4-Bromophenyl)-3-(methylthio)-3-phenylprop-2-en-1-one was ascertained by spectroscopic and single crystal X-ray diffraction analyses.

Recommanded Product: Methyl 2-cyanoacetate, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Category: nitriles-buliding-blocks.

Shen, Yuqing;Yuan, Chaoping;Zhu, Xianyi;Chen, Qin;Lu, Shenjun;Xie, Haibo research published 《 Engineering cellulose into water soluble poly(protic ionic liquid) electrolytes in the DBU/CO₂/DMSO solvent system as an organo catalyst for the Knoevenagel condensation reaction》, the research content is summarized as follows. Herein, linear water soluble cellulosic poly(protic ionic liquid) (CPIL) electrolytes were facilely and atom economically prepared after the dissolution of cellulose in the newly developed DBU/CO₂/DMSO solvent system, followed by the simple addition of succinic anhydride under mild conditions. The DBU not only participated in the dissolution of cellulose as a solvent component, but also acted as an organo catalyst for the acylation reaction of cellulose with succinic anhydride, as well as cation component in the targeted CPIL electrolytes. The reaction was optimized, and the effect of the reaction conditions on the chem. and phys. properties of the CPILs was investigated. The CPIL electrolyte aqueous solution was successfully used as the catalytic reaction media for the Knoevenagel condensation reaction. It was found that the reaction was homogeneous at the beginning, and the products could precipitate out from the media with the proceeding of the reaction, thus affording satisfactory filtration yields ranging from 56.7% to 93.8%. The solution properties of the CPIL aqueous solution were primarily investigated towards an in-depth understanding of the catalytic mechanism, by which a synergetic catalytic mechanism of the CPILs was proposed, and the reaction started with a nucleophilic addition reaction, and was then followed by a fast dehydration reaction. Finally, the direct reusability potential of the CPIL aqueous solution after the product filtration was also primarily investigated for the Knoevenagel condensation reaction.

Category: nitriles-buliding-blocks, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Application In Synthesis of 105-34-0.

Sheng, Xinyao;Xu, Qi;Lin, Ziwen;Hu, Zhongyan;Pan, Ling;Liu, Qun;Li, Yifei research published 《 External Reductant-free Stepwise [3+2] Cycloaddition/Reductive Cyclization from 2-Nitrochalcones and Isocyanides: Synthesis of Pyrrolo[3,4-c]quinoline N-oxides》, the research content is summarized as follows. A novel and unprecedented route for the synthesis of pyrrolo[3,4-c]quinoline N-oxides I [R = H, Cl, Br, Me, OMe; R¹ = H, Cl, Br, CF₃, OMe; R² = H, Cl, Br, Me; R³ = H, Br, Me, OMe; R⁴ = H, Cl, Br, Me, OMe; R³R⁴ = -CH=CHCH=CH-; R⁵ = Me, Et, t-Bu] is described. The synthetic approach involves a stepwise [3+2] cycloaddition/reductive cyclization from readily available 2-nitrochalcones 2-NO₂-4-R-5-R¹C₆H₂CH=CHC(O)(2-R²-3-R³-4-R⁴C₆H₂) and activated methylene isocyanides R⁵OC(O)CH₂CN. The unique feature of this transformation is the reductive cyclization of C-N bond forming without any external reductants. Moreover, the application of pyrrolo[3,4-c]quinoline N-oxides I is realized to formed pyrrolo[3,4-c]quinoline derivatives II (R = R² = H; R¹ = H, Br; R³ = H; R⁴ = H, Me, OMe; R³R⁴ = -CH=CHCH=CH-; R⁵ = Et, t-Bu).

Application In Synthesis of 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate.The prefix cyano- is used interchangeably with the term nitrile in literature. Computed Properties of 105-34-0.

Shin, Sangbin;Sim, Eunji;Lee, Wonjoo;Paik, Hyun-jong;Yu, Youngchang;Ahn, Dowon research published 《 Synthesis and reactivity of novel cinnamonitrile derivatives as reactive UV stabilizers for enhanced light protection and performance of coatings》, the research content is summarized as follows. UV light is generally harmful to human health and organic compounds (for example, plastics) as it deteriorates the long-term stability via photodegradation Thus, an efficient strategy for reducing light-induced damage is the key to maximizing the operation lifetime or durability of materials. The most common means of preventing UV light-induced damage is by adding compounds that possess excellent UV absorbing capability. In this study, novel cinnamonitrile derivatives were designed and synthesized for their application as UV absorbers in pressure-sensitive adhesives. Absorption wavelengths were finely tuned by simple structural modification, and better molar absorptivity was obtained. The hydroxyhexyl functional group affixed into the cinnamonitrile core granted superior solubility (>10 weight%) in common organic solvents and acrylic monomers/resins, instigating enhanced UV blocking and visible light transparency. Further, to enhance the solubility and long-term stability of UV absorbers within a network, hydroxyhexyl-functionalized cinnamonitrile UV absorber was incorporated into urethane-based crosslinkers. Covalently attached reactive UV absorbers improved the adhesion property even at a high loading of UV absorber and remarkable phys. persistence within the network.

Computed Properties of 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts