Category: 105-34-0

Inorganic compounds containing the −C≡N group are not called nitriles, but cyanides instead.105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Though both nitriles and cyanides can be derived from cyanide salts, most nitriles are not nearly as toxic. Application of C4H5NO2.

Yang, Liu;Chen, Suyuan;Yi, Dong;Chen, Qingxin;Zhang, Jie;Xie, Yusheng;Sun, Hongyan research published 《 Synthesis and fluorescence properties of red-to-near-infrared-emitting push-pull dyes based on benzodioxazole scaffolds》, the research content is summarized as follows. Fluorescence imaging with high temporal and spatial resolution has emerged as one of the most promising techniques to monitor biomols. and biol. processes in living systems. Among many kinds of small mol. fluorescent dyes, 2,1,3-benzoxadiazole (BD) derivatives have been widely applied in many chem. and biol. applications due to their excellent photophys. properties. However, only a limited number of BD dyes with long emission wavelengths were reported. Herein, we have reported a new class of red-to near-IR-emitting small mol. dyes 2a-3a based on benzodioxazole scaffolds, which are named VBDfluors. To bathochromically shift both absorption and emission, the conjugation system was extended by introducing electron-withdrawing group-substituted vinyl groups at position 7 via a Knoevenagel condensation reaction. The basic photophys. properties of VBDfluors were detected and summarized. The VBDfluors display excellent photophys. properties, including emission in the red-to-NIR region, large Stokes shifts, good stability/photostability and cell permeability. The geometry of the mols. was optimized by d. functional theory (DFT) and time-dependent DFT (TDDFT) methods. Bioimaging results indicated that 2a and 3a exhibited excellent cell permeability and could be utilized for visualization of lipid droplets in living cells.

Application of C4H5NO2, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Safety of Methyl 2-cyanoacetate.

Yavari, Issa;Mohsenzadeh, Ramin;Kayanian, Jasmine research published 《 Synthesis and structure of dialkyl (Z)-3-amino-2-cyano-4-diazopent-2-enedioates》, the research content is summarized as follows. Diazo-transfer reaction of tosyl azide and alkyl 2-cyanoacetates in the presence of pyridine at 0° gives the corresponding alkyl 2-cyano-2-diazoacetates. This material readily underwent nucleophilic attack by pyridinium 1-cyano-2-alkoxy-2-oxoethan-1-ide to form dialkyl (Z)-3-amino-2-cyano-4-diazopent-2-enedioates. The X-ray structure of a typical product is reported, as well as DFT computational studies that illuminate the structural features of these stable diazo compounds

Safety of Methyl 2-cyanoacetate, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Reference of 105-34-0.

Wang, Ziqian;Zhang, Xiaodong;Zhang, Hong;Tang, Yao;Pan, Hao;Wang, Hang;Ji, Tong;Guo, Yafei;Gao, Qishuang;Song, Ting;Zhang, Zhichao research published 《 Discovery of a fluorogenic probe for in situ pyruvate kinase M2 isoform (PKM2) labeling through chemoselective S_NAr with a binding site lysine residue》, the research content is summarized as follows. The key challenge of developing reaction-based turn-on probes is to establish latent electrophilic fluorophores exhibiting high reactivity only upon binding to a specific protein(s). Herein, we identified such a fluorophore, 6-arylthioether-substituted 3-cyano-1-oxo-1H-phenalene-2-carboxylate, which chemoselectively labels binding site Cys or Lys residues. Based on this fluorophore, we developed the first reaction-based turn-on pyruvate kinase M2 isoform (PKM2) fluorescent probe AT-OPC1, which selectively labels PKM2 with the binding site Lys305. The latent electrophilic reactivity of the fluorophore endows the probe with precise detection of the expression of PKM2 in situ by means of both in-gel fluorescence imaging at the proteome level and real-time no-wash cell imaging approaches, which has the potential to be applied in cancer diagnoses.

Reference of 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Quality Control of 105-34-0.

Wu, Feng;Du, Juan;Liu, Na;Xu, Jie;Xue, Bing research published 《 Potassium-doped carbon nitride supported on SBA-15 for enhanced catalytic Knoevenagel condensation under mild conditions》, the research content is summarized as follows. Knoevenagel condensation reaction is an important reaction for the manufacture of α,β-unsaturated carbonyl compounds Traditional base catalysts suffer from the disadvantage in catalyst-product separation Herein, potassium-doped carbon nitride materials supported on SBA-15 (CN/SBA15-KCl) have been prepared through a one-pot calcination method. The characterization results of N₂ adsorption-desorption, small-angle XRD, TEM, and SEM revealed that the ordered mesostructures of SBA-15 had been preserved after the loading of carbon nitride and KCl, and nitrogen and potassium species were dispersed on the surface of SBA-15 support. As solid bases, the CN/SBA15-KCl materials demonstrated high and steady catalytic performances in Knoevenagel condensation. Under 50°C of reaction temperature, the optimized conversion of benzaldehyde was up to 74% at 4 h of reaction time, much higher than other carbon-nitride-based materials. The incorporation of potassium has been proved to enhance the basic strength of CN/SBA15, and therefore improved the catalytic activity.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Quality Control of 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. HPLC of Formula: 105-34-0.

Xie, Xiaofei;Wang, Lei;Zhou, Quan;Ma, Yongmin;Wang, Zhi-Ming;Li, Pinhua research published 《 Visible-light-induced novel cyclization of 2-(2-(arylethynyl)benzylidene)-malononitrile derivatives with 2,6-di(tert-butyl)-4-methylphenol to bridged spirocyclic compounds》, the research content is summarized as follows. A green and highly efficient strategy for the preparation of bridged spirocyclic compounds via visible-light-induced cyclization of 2-(2-(arylethynyl)benzylidene)malononitrile derivatives with 2,6-di(tert-butyl)-4-methylphenol (BHT) at room temperature was developed. The photoinduced radical reactions generated the corresponding products in good yields under simple and mild reaction conditions.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., HPLC of Formula: 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile is any organic compound with a −C≡N functional group. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate.The prefix cyano- is used interchangeably with the term nitrile in literature. Name: Methyl 2-cyanoacetate.

Xie, Zongbo;Li, Hongxia;Wang, Bo;Wu, Zhiwen;Le, Zhanggao research published 《 One-pot rapid synthesis of 4H-1-benzopyran derivatives in a deep eutectic solvent》, the research content is summarized as follows. Introduced 2-methylquinoline into the 4-position of 2-amino-4H-1-benzopyran scaffolds through a one-pot method using a deep eutectic solvent (DES) to serve as both solvent and catalyst. Choline chloride/glucose (1:1 molar ratio) was used as both the solvent and catalyst in the reaction of a salicylaldehyde, methylquinoline, and cyanoacetate to obtain 2-amino-4H-1-benzopyran derivatives in 48%-80% yields after short reaction times. The effects of the deep eutectic solvent type, substrate molar ratio, cosolvent, temperature, and reaction time were examined

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Name: Methyl 2-cyanoacetate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. COA of Formula: C4H5NO2.

Xie, Zongbo;Li, Hongxia;Yang, Jiangnan;Zhu, Xiao;Le, Zhanggao research published 《 One-Pot Synthesis of 4H-Pyrano[3,2-c]coumarin Derivatives Catalyzed by Deep Eutectic Solvent》, the research content is summarized as follows. An efficient and green method was developed to obtain 4H-pyrano[3,2-c]coumarin derivatives I [R¹ = H, Me, Cl; R² = H, 4-Me, 4-Cl, etc.; R³ = Me, Et, Pr, Bu] via reaction of aromatic aldehydes, 4-hydroxycoumarin and cyanoacetates using deep eutectic solvent (DES) zinc chloride/acetamide (n:n = 1:4), which acted as both the catalyst and the solvent for the reaction. The DES, substrate molar ratio, diluent type, temperature, and reaction time were optimized to obtain the 4H-pyrano[3,2-c]coumarin derivatives I from a range of aromatic aldehydes in a single step in moderate to high yields and under mild reaction conditions.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., COA of Formula: C4H5NO2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Computed Properties of 105-34-0.

Xu, Hui;Weng, Ming-Yue;Chen, Hong;Zhang, Ze research published 《 Unexpected Iodine-Promoted Aerobic Oxidation of α-Cyano-δ-keto Esters: A Facile Synthesis of α,δ-Dicarbonyl Esters》, the research content is summarized as follows. An efficient and green method for the synthesis of various α,δ-dicarbonyl esters R¹C(O)CH₂CH(R²)C(O)C(O)OR³ (R¹ = Me, Ph, 2-naphthyl, 2-furanyl, etc.; R² = Ph, 3-methylphenyl, 2,4-dichlorophenyl, etc.; R³ = Me, Et) has been developed via a conjugate addition of ethyl/methyl cyanoacetate to chalcones R¹C(O)CH=CHR² and subsequent iodine-promoted aerobic oxidation The present protocol features mild reaction conditions, high efficiency, easily available starting materials, and broad substrate scope.

Computed Properties of 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion. Electric Literature of 105-34-0.

Xu, Jimin;Xie, Xuping;Chen, Haiying;Zou, Jing;Xue, Yu;Ye, Na;Shi, Pei-Yong;Zhou, Jia research published 《 Design, synthesis and biological evaluation of spiropyrazolopyridone derivatives as potent Dengue virus inhibitors》, the research content is summarized as follows. The effective treatment for dengue virus infection continues to be a challenge. The authors herein reported the authors’ continued SAR exploration on the spiropyrazolopyridone scaffold. Introducing different substituents at the 3-́ or 5-́site of the pyrazolopyridone core or moving the benzyl chain to the adjacent nitrogen led to a significant loss of potency on DENV-2. While a narrow range of substitutions were tolerated at the para-position of the Ph ring, di-substitution on the Ph ring is beneficial for DENV-2 potency and has variable influences on DENV-3 potency depending on the exact compound Among these mols., compounds (JMX0376) with 4-chloro-3-fluorobenzyl and (JMX0395) with 2,4-bis(trifluoromethyl)benzyl showed the most potent and broadest inhibitory activities against DENV-1 to -3 with nanomolar to low micromolar EC₅₀ values.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Electric Literature of 105-34-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Both routes are green in the sense that they do not generate stoichiometric amounts of salts. Recommanded Product: Methyl 2-cyanoacetate.

Wang, Nengzhong;Lang, Yimin;Wang, Junjie;Wu, Zugen;Lu, Yixin research published 《 Phosphine-Catalyzed Sequential [3 + 2]/[3 + 2] Annulation between Allenoates and Arylidenemalononitriles for the Enantioselective Construction of Bicyclo[3,3,0]octenes and Cyclopenta[c]quinolinones》, the research content is summarized as follows. A highly diastereo- and enantioselective phosphine-catalyzed sequential [3+2]/[3+2] annulation of allenoates CH₂=C=CHC(O)OR (R = Bn, Me, Et, t-Bu, diphenylmethyl) with arylidenemalononitriles R¹CH=C(CN)₂ (R¹ = 2-nitrophenyl, 6-nitro-2H-1,3-benzodioxol-5-yl, 5-nitrothiophen-2-yl, etc.) has been developed. This reaction allows for the facile construction of multifunctionalized cis-fused bicyclic[3,3,0]octene scaffolds I, encompassing three consecutive stereogenic centers with one quaternary carbon center, in a one-step operation from readily available materials. The reported protocol is scalable, operates under mild reaction conditions, and creates the core structural motif of a number of natural products.

105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Recommanded Product: Methyl 2-cyanoacetate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts