Category: 105-34-0

Synthetic Route of 105-34-0,Some common heterocyclic compound, 105-34-0, name is Methyl 2-cyanoacetate, molecular formula is C4H5NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 10 mL round-bottomed flask was charged with carbonyl compound (1 mmol), active methylene compound (1 mmol), S-4 (12 mg and 20 mol% of the substrates), and water (3 mL). The reaction mixture was stirred at room temperature. The suspension was stirred at room temperature for the lengths of time shown in Table 4. The reaction progress was monitored by thin layer chromatography usingn-hexane-EtOAc (5:1) as eluent. After completing the reaction, the reaction mixture solidified in the round-bottomed flask. The solids were then dissolved in hot ethanol (30 mL). The catalyst was removed by filtration and washed with ethanol. The solid product was obtained after the ethanol was concentrated in vacuo.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-cyanoacetate, its application will become more common.

Reference:
Article; Zhao, Xian-Liang; Yang, Ke-Fang; Zhang, Yan-Ping; Zhu, Ju; Xu, Li-Wen; Chinese Chemical Letters; vol. 25; 8; (2014); p. 1141 – 1144;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 105-34-0, name is Methyl 2-cyanoacetate, A new synthetic method of this compound is introduced below., name: Methyl 2-cyanoacetate

1-nitro-naphthalene (97 g, 0.56 mol), methyl cyanoacetate (166.5 g, 1.68 mol), potassium cyanide (40.1 g, 0.62mol), potassium hydroxide (62.9 g, 1.12 mol) and dissolved in dimethylformamide (970 mL) and the mixture was stirred overnight at 60C. After concentrated under reduced pressure to remove the solvent at room temperature into a 500 mL 10% aqueous sodium hydroxide solution was refluxed for about one hour. After extraction with ethyl acetate and separated by column chromatography and recrystallized from toluene-heptane to give the Sub 2-2-1 50.8 g (yield: 54%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 105-34-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105-34-0, name is Methyl 2-cyanoacetate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

97 g (0.56 mol) of 1-nitronaphthalene,166.5 g (1.68 mol) of methyl cyanoacetate,40.1 g (0.62 mol) of potassium cyanide,62.9 g (1.12 mol) of potassium hydroxide,And the mixture was stirred.Dimethylformamide 970 mLAnd the mixture was stirred overnight at 60 C.After the solvent was removed by concentration under reduced pressure at room temperature, 10%500 mL of an aqueous solution of sodium hydroxide was added and the mixture was refluxed for about 1 hour.After separation by column chromatography, recrystallization from toluene and heptane gave 50.8 g of intermediate 4-a. (Yield: 54%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-cyanoacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SFC Ltd.; Choi Yeong-tae; Lee Se-jin; Park Seok-bae; Ryu Tae-jeong; Yang Byeong-seon; Lee Da-jeong; (92 pag.)KR2018/10087; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 105-34-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 105-34-0, name is Methyl 2-cyanoacetate belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of aromatic aldehyde (10 mmol) and active methylene compound(10 mmol) in 10 mL ethanol was introduced in a 20 mL heavy walled pearshapedtwo-necked flask with nonstandard taper outer joint. The flask wasattached to a 12 mm tip diameter probe and the reaction mixture wassonicated at ambient temperature for the specified period at 50% power of theprocessor and 230W output in a 4 s pulse mode. At the end of the reactionperiod, TLC was checked and the flask was detached from the probe and thecontent was transferred into a beaker. The formed solid was filtered off andwashed thoroughly with cold ethanol (2 10 ml) to afford the Knoevenageladduct 3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-cyanoacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Dandia, Anshu; Jain, Anuj K.; Laxkar, Ashok K.; Bhati, Dharmendra S.; Tetrahedron Letters; vol. 54; 24; (2013); p. 3180 – 3184;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 105-34-0, name is Methyl 2-cyanoacetate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C4H5NO2

A mixture of cyano-acetic acid methyl ester (1 1 g, 11 1 mmol), CS2CO3 (108 g, 333 mmol) and methyl iodide (35 mL, 556 mmol) in anhydrous DMF (300 mL) was stirred at r.t. for 3 days. Brine (100 mL) and ether (250 mL) were added, and the aqueous layer was extracted with additional ether (250 mL). The organic layers were combined, washed with water (4 x 200 mL), and dried over MgSO/t. The solvent was evaporated to give 1 1 g of the title compound as a yellow oil. lH NMR (CDCI3, 200 MHz): 8ppm= 3.83 (s, 3H), 1.63 (s, 6H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 105-34-0.

Reference:
Patent; FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.; WO2013/134660; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 105-34-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 105-34-0 as follows.

The mixture of benzaldehyde (0.5 mmol) and methyl cyanoacetate(0.5 mmol) in toluene 1 mL was incubated in the presence of Candida cylindracea lipase (30 mg) at 50 C for 4 days. The reaction was monitored by TLC analysis. After this time enzyme was filtered out and the solvent was evaporated in vacuo. The resulting residue was purified by column chromatography (silica gel, eluent ethyl acetate/hexanes) to obtain desired product 5a with 40% yield. 4.7. Characterization of obtained products 5a-u.4.7.1. Methyl (E)-2-cyano-3-phenylprop-2-enoate; (5a)White solid; melting point 89 C; 1H NMR (400 MHz, CDCl3) delta 8.20(s, 1H), 7.92 (dd, J=7.1, 1.5 Hz, 2H), 7.53-7.40 (m, 3H), 3.87 (s, 3H).13C NMR (100 MHz, CDCl3) delta 162.9, 155.3, 133.4, 131.4, 131.1, 129.3,115.4, 102.6, 53.4. All the resonances of 1H, 13C NMR spectra andmelting point were consistent with reported values [32]

According to the analysis of related databases, 105-34-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wilk, Monika; Trzepizur, Damian; Koszelewski, Dominik; Brodzka, Anna; Ostaszewski, Ryszard; Bioorganic Chemistry; vol. 93; (2019);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

105-34-0, A common heterocyclic compound, 105-34-0, name is Methyl 2-cyanoacetate, molecular formula is C4H5NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Benzaldehyde SI-10 (1.59 g, 15 mmol, 1.0 equiv) and methyl 2-cyanoacetate SI-6 (1.59 g, 16 mmol 1.1 equiv) were dissolved in 50 mL acetonitrile and polymer bound dimethyl benzylamine (QP-DMA, 10 g) were added. The whole mixture was stirred under N2 at 80 C for 18 h. The solvent was then removed under reduced pressure and the crude solid was recrystallised from ethanol to give 1.64 g ofwhite crystals. Isolated yield: 1.64 g (58%, 15 mmol)

The synthetic route of 105-34-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mallia, Carl J.; Englert, Lukas; Walter, Gary C.; Baxendale, Ian R.; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 875 – 883;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts