Category: 104798-53-0

Mowbray, Charles E. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2009 | CAS: 104798-53-0

2-Fluoro-5-hydroxybenzenecarbonitrile (cas: 104798-53-0) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Reference of 104798-53-0

Pyrazole NNRTIs 3: Optimisation of physicochemical properties was written by Mowbray, Charles E.;Corbau, Romuald;Hawes, Michael;Jones, Lyn H.;Mills, James E.;Perros, Manos;Selby, Matthew D.;Stupple, Paul A.;Webster, Rob;Wood, Anthony. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Reference of 104798-53-0 This article mentions the following:

Our efforts to reduce overall lipophilicity and increase ligand-lipophilicity efficiency (LLE) by modification of the 3- and 5-substituents of pyrazole I, a novel non-nucleoside HIV reverse transcriptase inhibitor (NNRTI) prototype were unsuccessful. In contrast replacement of the substituted benzyl group with corresponding phenylthio or phenoxy groups resulted in marked improvements in potency, ligand efficiency (LE) and LLE. In the experiment, the researchers used many compounds, for example, 2-Fluoro-5-hydroxybenzenecarbonitrile (cas: 104798-53-0Reference of 104798-53-0).

2-Fluoro-5-hydroxybenzenecarbonitrile (cas: 104798-53-0) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Reference of 104798-53-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Claffey, Michelle M. et al. published their research in Journal of Medicinal Chemistry in 2012 | CAS: 104798-53-0

2-Fluoro-5-hydroxybenzenecarbonitrile (cas: 104798-53-0) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Recommanded Product: 2-Fluoro-5-hydroxybenzenecarbonitrile

Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors was written by Claffey, Michelle M.;Helal, Christopher J.;Verhoest, Patrick R.;Kang, Zhijun;Bundesmann, Mark W.;Hou, Xinjun;Lui, Shenping;Kleiman, Robin J.;Vanase-Frawley, Michelle;Schmidt, Anne W.;Menniti, Frank;Schmidt, Christopher J.;Hoffman, William E.;Hajos, Mihaly;McDowell, Laura;O’Connor, Rebecca E.;MacDougall-Murphy, Mary;Fonseca, Kari R.;Becker, Stacey L.;Nelson, Frederick R.;Liras, Spiros. And the article was included in Journal of Medicinal Chemistry in 2012.Recommanded Product: 2-Fluoro-5-hydroxybenzenecarbonitrile This article mentions the following:

Phosphodiesterase 9A inhibitors have shown activity in preclin. models of cognition with potential application as novel therapies for treating Alzheimer’s disease. Our clin. candidate, PF-04447943 (2), demonstrated acceptable CNS permeability in rats with modest asymmetry between central and peripheral compartments (free brain/free plasma = 0.32; CSF/free plasma = 0.19) yet had physicochem. properties outside the range associated with traditional CNS drugs. To address the potential risk of restricted CNS penetration with 2 in human clin. trials, we sought to identify a preclin. candidate with no asymmetry in rat brain penetration and that could advance into development. Merging the medicinal chem. strategies of structure-based design with parallel chem., a novel series of PDE9A inhibitors was identified that showed improved selectivity over PDE1C. Optimization afforded preclin. candidate 19 that demonstrated free brain/free plasma ≥1 in rat and reduced microsomal clearance along with the ability to increase cyclic guanosine monophosphosphate levels in rat CSF. In the experiment, the researchers used many compounds, for example, 2-Fluoro-5-hydroxybenzenecarbonitrile (cas: 104798-53-0Recommanded Product: 2-Fluoro-5-hydroxybenzenecarbonitrile).

2-Fluoro-5-hydroxybenzenecarbonitrile (cas: 104798-53-0) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Recommanded Product: 2-Fluoro-5-hydroxybenzenecarbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts