Category: 10412-93-8

Related Products of 10412-93-8, A common heterocyclic compound, 10412-93-8, name is N-Benzyl-2-cyanoacetamide, molecular formula is C10H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 3 Reaction of 3,4-methylenedioxycinnamaldehyde with 2-benzylamidoacrylonitrile, Knoevenagel Reaction 2.0 g (11.13 mmol) of the product from Example 2 (3,4-methylenedioxycinnamaldehyde), 76.8 g of ethanol (absolute) and 0.1093 g of piperidine were initially introduced into a 250 mL three-necked round-bottomed flask. The suspension was stirred at room temperature for 1 hour to dissolve the crystals. Then, 2.26 g of (cyanoacetyl)benzamide were added to the reaction mixture. This solution was stirred for 6-8 hours, during which a suspension was formed. After 6-8 hours, the suspension was filtered off and the residue (3.4 g of yellow, moist crystals) was washed with a small amount of absolute ethanol. This residue was dried overnight in a drying cabinet at 40 C. and about 20 mbar. Drying gave 2.7 g of (E,E)-2-(benzylamido)-3-(3,4-methylenedioxystyryl)acrylonitrile (yield: 71%) as yellow crystals. The identity and purity were confirmed by means of 1H NMR and HPLC.

The synthetic route of 10412-93-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LymphoSign Inc.; US2005/33090; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10412-93-8, name is N-Benzyl-2-cyanoacetamide, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H10N2O

General procedure: N-benzyl-2-cyanoacetamide (1) was synthesized from benzylamineand ethyl cyanoacetate following the reported procedure[30] (Table 1).A mixture of N-benzyl-2-cyanoacetamide (1 mmol),aromatic aldehydes (1 mmol), 2-naphthol (1 mmol)and piperidine (0.1 mmol) in absolute EtOH (5 ml) wasrefluxed for an appropriate time as shown in Table 2. The reaction progress was monitored by TLC. After completionof the reaction, the mixture was cooled to r.t and thenH2O(5 mL) was added. The solid product was filtered,washed with cold distilled water (2 mL) to obtain essentiallypure products. The solid products were recrystallizedfrom ethanol.The structure of the products was characterized by IR, 1Hand 13C NMR spectra along with elemental analysis data.

According to the analysis of related databases, 10412-93-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Pouramiri, Behjat; Tavakolinejad Kermani, Esmat; Khaleghi, Moj; Journal of the Iranian Chemical Society; vol. 14; 11; (2017); p. 2331 – 2337;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

10412-93-8, These common heterocyclic compound, 10412-93-8, name is N-Benzyl-2-cyanoacetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of N-alkyl-2-cyano-acetamides 1a-c (2 mmol), aldehydes 2a-f (2 mmol),malononitrile (3) (2 mmol), K2CO3 (2 mmol), and EtOH (2 mL) in a 10 mL septum-capped microwavevials was irradiated under microwave conditions at 90 C, 500 W, 200 rpm, for 10-15 min. Aftercompletion of the reaction, as indicated by TLC, each vial was de-capped and the contents were left tocool to room temperature. Then, the reaction mixture was worked up as described in method I to givecompounds 4a-q. Analytical samples were obtained by recrystallization from MeOH.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10412-93-8.

Reference:
Article; Mekheimer, Ramadan Ahmed; Al-Sheikh, Mariam Abdullah; Medrasi, Hanadi Yousef; Alsofyani, Najla Hosain Hassan; Molecules; vol. 23; 3; (2018);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts