Category: 10412-93-8

These common heterocyclic compound, 10412-93-8, name is N-Benzyl-2-cyanoacetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C10H10N2O

General procedure: A mixture of N-alkyl-2-cyano-acetamides 1a-c (2 mmol), aldehydes 2a-f (2 mmol),malononitrile (3) (2 mmol), K2CO3 (2 mmol), and EtOH (2 mL) in a 10 mL septum-capped microwavevials was irradiated under microwave conditions at 90 C, 500 W, 200 rpm, for 10-15 min. Aftercompletion of the reaction, as indicated by TLC, each vial was de-capped and the contents were left tocool to room temperature. Then, the reaction mixture was worked up as described in method I to givecompounds 4a-q. Analytical samples were obtained by recrystallization from MeOH.

The synthetic route of N-Benzyl-2-cyanoacetamide has been constantly updated, and we look forward to future research findings.

Reference:
Article; Mekheimer, Ramadan Ahmed; Al-Sheikh, Mariam Abdullah; Medrasi, Hanadi Yousef; Alsofyani, Najla Hosain Hassan; Molecules; vol. 23; 3; (2018);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Application of 10412-93-8, These common heterocyclic compound, 10412-93-8, name is N-Benzyl-2-cyanoacetamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5.6. Synthesis Of (E)-2-(benzylaminocarbonyl)-3-(3-iodo-4,5-dihydroxyphenyl)acrylonitrile A preferred method of synthesis of (E)-2-(benzylaminocarbonyl)-3-(3-iodo-4,5-dihydroxyphenyl)acrylonitrile (Compound 6) is as follows: A mixture of 0.4 g of 2-cyano-3-(4-hydroxy-3-iodo-5-methoxy)phenylacrylonitrile (which was prepared by condensation of 4-hydroxy-3-iodo-5-methoxybenzaldehyde with N-benzylcyanoacetamide) and 0.5 ml of BBr3 in 20 ml dichloromethane was stirred for 2 hours at room temperature. Workup (H2 O, ethyl acetate) gave 0.16 g of a yellow solid (41 yield) having a melting point of 220 C. The product gave the following analytical data: NMR (acetone-d6) delta 8.05(1H,S,vinyl), 7.85(1H,d,J=2.1 Hz), 7.70(1H,d,J=2.1 Hz), 7.30(5H,in), 4.6(2H,S).

Statistics shows that N-Benzyl-2-cyanoacetamide is playing an increasingly important role. we look forward to future research findings about 10412-93-8.

Reference:
Patent; Sugen, Inc.; Yissum Research Development Co. of the Hebrew University of Jerusalem; US5792771; (1998); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10412-93-8, name is N-Benzyl-2-cyanoacetamide belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 10412-93-8

To 3, 4-dihydroxycinnamaldehyde A12 (example 59) (32 mg, 0.2 mmol) and amide A3 (Example 4) (32 mg, 0.2 mmol) in 8 mL of ethanol 40 gl of piperidine was added and the mixture was kept at room temperature for 1 h. 2N HCI and water were added and the precipitated solid was recrystallized from ethanol-water to give 44 mg (68%) of an orange solid. The analytical data were identical to the compound prepared as described in Example 8.

The synthetic route of 10412-93-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP; WO2005/92904; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 10412-93-8, name is N-Benzyl-2-cyanoacetamide, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10412-93-8, Quality Control of N-Benzyl-2-cyanoacetamide

General procedure: To a stirred solution of cyanamide (2, 1.1 mmol) in ethanol (2 mL) were added 2-hydroxybenzaldehyde (1 mmol) and piperidine(catalytic amount), and the resulting mixture was stirred at room temperature for 12 h. The suspension was then filtered to give 4, which was used directly in the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Benzyl-2-cyanoacetamide, and friends who are interested can also refer to it.

Reference:
Article; Endo, Satoshi; Hu, Dawei; Suyama, Miho; Matsunaga, Toshiyuki; Sugimoto, Kenji; Matsuya, Yuji; El-Kabbani, Ossama; Kuwata, Kazuo; Hara, Akira; Kitade, Yukio; Toyooka, Naoki; Bioorganic and Medicinal Chemistry; vol. 21; 21; (2013); p. 6378 – 6384;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 10412-93-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10412-93-8 name is N-Benzyl-2-cyanoacetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: (E)–aryl–cyanoacrylamides 2 was prepared according to literature procedure.2 General procedure for 2a. To a solution of benzaldehyde (10 mmol 1.0 equiv), pyrrolidine (2 mmol, 20 mol %) in ethanol (20 mL) was added N-benzyl-2-cyanoacetamide (10 mmol, 1.0 equiv). The reaction mixture was stirred at room temperature until the reaction was complete (monitored by TLC), the solvent was removed under reduced pressure. The crude reaction mixture was purified through flash column chromatography on silica gel to afford 2a.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Benzyl-2-cyanoacetamide, and friends who are interested can also refer to it.

Reference:
Article; Nie, Xufeng; Wang, Yachuan; Yang, Lijun; Yang, Zaijun; Kang, Tairan; Tetrahedron Letters; vol. 58; 31; (2017); p. 3003 – 3007;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 10412-93-8, name is N-Benzyl-2-cyanoacetamide, molecular formula is C10H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 10412-93-8

General procedure: (E)–aryl–cyanoacrylamides 2 was prepared according to literature procedure.2 General procedure for 2a. To a solution of benzaldehyde (10 mmol 1.0 equiv), pyrrolidine (2 mmol, 20 mol %) in ethanol (20 mL) was added N-benzyl-2-cyanoacetamide (10 mmol, 1.0 equiv). The reaction mixture was stirred at room temperature until the reaction was complete (monitored by TLC), the solvent was removed under reduced pressure. The crude reaction mixture was purified through flash column chromatography on silica gel to afford 2a. 1H NMR (CDCl3, 400 MHz): delta (ppm) 8.68 (s, 1H), 7.78-7.74 (m, 1H), 7.70 (dd, J = 7.6, 1.4 Hz, 1H), 7.43 (t, J = 7.6 Hz, 1H), 7.30 (d, J = 8.0 Hz, 1H); 13C NMR (CDCl3, 100 MHz): delta (ppm) 167.9, 154.4, 137.8, 131.0, 126.4, 118.8, 115.6.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 10412-93-8, its application will become more common.

Reference:
Article; Nie, Xufeng; Wang, Yachuan; Yang, Lijun; Yang, Zaijun; Kang, Tairan; Tetrahedron Letters; vol. 58; 31; (2017); p. 3003 – 3007;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10412-93-8, name is N-Benzyl-2-cyanoacetamide, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks

EXAMPLE 6 Synthesis of Cyanoester G Cinnamaldehyde E (11.0 g; corrected with the HPLC purity) was dissolved in methanol (500 g). The solution was filtered over a nutsch, which is rinsed with methanol (80 g). At 20-25 C., intermediate F (8.5 g) was added in one portion to the methanolic solution followed by the addition of piperidine (9.1 g) in several portions. The deep red solution was stirred for at least 3 hours and an in-process control performed. Upon total conversion of starting material, 370 g of methanol was distilled off at 4045 C. To the resulting residue was added 16.6 g of HCl (32%) and water (150 g). The color changed from red to yellow and the product precipitated out of solution provided that pH was between 1 and 1.3. The suspension was then cooled to 0-5 C. and stirred for at least 2-3 hours (up to 20 hours) to maximize the yield. The suspension was then filtered via a nutsch and the residue rinsed with water (25 g) to yield 15.1 g of G. The wet G (15 g) was then suspended in acetonitrile (600 g) and heated to 80-82 C. for 1 h. The suspension was then cooled to 0-5 C. and stirred for at least 3 h. The wet material was separated with a nutsch and rinsed twice with a mixture of ethanol (10 g) and water (20 g). Final drying in the vacuum dryer at 45 C. yields 10.2 g of yellowish G in an overall yield of 56% (over two steps).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LymphoSign Inc.; US2005/33090; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 10412-93-8,Some common heterocyclic compound, 10412-93-8, name is N-Benzyl-2-cyanoacetamide, molecular formula is C10H10N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 5 (1.5 mmol) and 2a-s (3.1 mmol) in ethanol (10 mL) was added Et3N (0.1 mmol) dropwise at room temperature. The resulting mixture was stirred at 50 C for 2-3 h and then allowed to cool to room temperature. The product was precipitated from the reaction mixture, collected by filtration and washed with methanol (2-3 mL) to yield corresponding final products (6a-s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N-Benzyl-2-cyanoacetamide, its application will become more common.

Reference:
Article; Shaik, Jeelan Basha; Palaka, Bhagath Kumar; Penumala, Mohan; Kotapati, Kasi Viswanath; Devineni, Subba Rao; Eadlapalli, Siddhartha; Darla, M. Manidhar; Ampasala, Dinakara Rao; Vadde, Ramakrishna; Amooru, G. Damu; European Journal of Medicinal Chemistry; vol. 107; (2016); p. 219 – 232;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 10412-93-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10412-93-8 name is N-Benzyl-2-cyanoacetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Under N2 atmosphere, t-BuOK (246 mg, 2.2 mmol) and various acetamides 2 (1.0 mmol) in dry THF (5 mL) were placed in a 10 mL Schlenk flask at -78 C. The suspension was warmed to room temperature for 30 min and recooled to -78 C. (Z)-methyl-bromo-4,4,4-trifluorobut-2-enoate 1 (117 mg, 0.5 mmol) was added at this temperature. The solution was stirred at this temperature until the reaction was completed (usually 15-30 min), followed by adding saturated aqueous NH4Cl solution (10 mL). The solution mixture was extracted with EtOAc (3×10 mL), and the combined organic layer was washed with brine, then, dried over Na2SO4. After removal of solvents under vacuum, the crude product was further purified by silica gel column chromatography (PE:EA = 1:2 v/v) to afford pure product 4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-Benzyl-2-cyanoacetamide, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10412-93-8, name is N-Benzyl-2-cyanoacetamide, A new synthetic method of this compound is introduced below., Recommanded Product: N-Benzyl-2-cyanoacetamide

General procedure: A mixture of 3-hydroxy-3-methylbutan-2-one 1 (10 mmol) and the substituted cyanoacetamides 2a-d (10 mmol) with a solution of sodium ethoxide (0.5 mmol) in ethanol (10 mL) was stirred at room temperature. After evaporation of the solvent, the residue was acidified with 6 M aqueous HCl. The mixture was neutralised with a solution of potassium carbonate (10%), then extracted with CH2Cl2 (3×25 mL). The combined organic layers were dried on MgSO4, filtered and concentrated in vacuum. The recovered solid was recrystallised in ethanol to provide compounds 3a-d.

The synthetic route of 10412-93-8 has been constantly updated, and we look forward to future research findings.