Category: 10406-25-4

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10406-25-4 name is 4-(Aminomethyl)benzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 10406-25-4

General procedure: Under nitrogen atmosphere, a Schlenk tube was sequentially charged with cyclicdiaryliodonium salt (1.0 equiv), copper catalyst A1 or A2 (5.0 mol%), Na2CO3 (3.0 equiv) anddichloromethane (0.05 M). After the mixture was chilled to proper temperature, the appropriateamine (1.2 equiv) was added and stirred for the time indicated in the experimental procedures.The reaction mixture was filtered through a plug of celite with ethyl acetate. The filtrate wasconcentrated under reduced pressure, and the residue was purified by column chromatographyon silica gel to deliver the corresponding product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-(Aminomethyl)benzonitrile, and friends who are interested can also refer to it.

Reference:
Article; Zhao, Kun; Duan, Longhui; Xu, Shibo; Jiang, Julong; Fu, Yao; Gu, Zhenhua; Chem; vol. 4; 3; (2018); p. 599 – 612;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

10406-25-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10406-25-4, name is 4-(Aminomethyl)benzonitrile, A new synthetic method of this compound is introduced below.

Biphenyl-3 -carboxylic acid (500mg, 2. 52mmol) and 4-aminomethyl-benzonitrile (425mg, 2.S2mmol) were suspended in DCM (25mL) and DIPEA (873uL, 5.O4mmol), EDC (484mg, 2.S2mmol) and HOBt (3 86mg, 2.S2mmol) were added. The reactionmixture was stirred overnight, concentrated in vacuo and partitioned between EtOAc (lOOmL) and water (lOOmL). The organic fraction was washed with water (lOOmL), sat aq NaHCO3 (5OmL), brine (5OmL), dried (MgSO4) and concentrated in vacuo to give the title compound (738mg, 94%) as a brown solid. LCMS: ES 313.0 [IVIHf.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PROXIMAGEN LIMITED; MEO, Paul; STEWART, Alison; HOBBS, Christopher; WO2014/20351; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

10406-25-4,Some common heterocyclic compound, 10406-25-4, name is 4-(Aminomethyl)benzonitrile, molecular formula is C8H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 87 Preparation of 4-(aminomethyl)phenyl-N-hydroxyamidine (4-4) Hydroxylamine hydrochloride (7 g) was added to a solution of compound 4-3 (7 g) and NMM (4 ml) in methanol (100 ml). The mixture was stirred at ambient temperature for 3 days. The compound was purified by RP HPLC to give the title compound (7 g, 89%). MS (electrospray): 166 (M+1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Aminomethyl)benzonitrile, its application will become more common.

Reference:
Patent; Corvas International, Inc.; US2002/37857; (2002); A1;; ; Patent; Corvas International, Inc.; US6586405; (2003); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

10406-25-4, name is 4-(Aminomethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 10406-25-4

General procedure: Biphenyl-3-carboxylic acid (500mg, 2.52mmol) and 4-aminomethyl-benzonitrile (425mg, 2.52mmol) were suspended in DCM (25mL) and DIPEA (873uL, 5.04mmol), EDC (484mg, 2.52mmol) and HOBt (386mg, 2.52mmol) were added. The reaction mixture was stirred overnight, concentrated in vacuo and partitioned between EtOAc (lOOmL) and water (lOOmL). The organic fraction was washed with water (l OOmL), sat aq NaHCC>3 (50mL), brine (50mL), dried (MgSC ) and concentrated in vacuo to give the title compound (738mg, 94%) as a brown solid. LCMS: ES+ 313.0 [MH]+.

Statistics shows that 10406-25-4 is playing an increasingly important role. we look forward to future research findings about 4-(Aminomethyl)benzonitrile.

Reference:
Patent; PROXIMAGEN LIMITED; MEO, Paul; STEWART, Alison; HOBBS, Christopher; HIGGINBOTTOM, Michael; WO2014/20350; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts