Category: 10406-24-3

Synthetic Route of 10406-24-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10406-24-3, name is 3-(Aminomethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 2 m-Cyanobenzylamine (13.2 g), sodium nitrite (10.4 g), and dimethylformamide (100 ml) were mixed together, and the mixture was vigorously stirred at room temperature. Trifluoroacetic acid (22.8 g) was added dropwise to the mixture over one hour. After completion of addition, the mixture was further allowed to react at 100 C. for one hour. For the subsequent process, the procedure of Example 1 was repeated, to thereby obtain 6.9 g of m-cyanobenzyl alcohol (bp. 128-130 C./400 Pa) (yield 52%). The purity of the product was 98%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Aminomethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Showa Denko K.K.; US6187945; (2001); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electric Literature of 10406-24-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10406-24-3, name is 3-(Aminomethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 12; By removing ammonia by evaporation from the second hydrogenation product solution discharged from the outlet of the reaction tube B which was obtained in Example 2, a crude xylylenediamine containing 92.1% by weight of m-xylylenediamine and 520 ppm by weight of 3-cyanobenzylamine was obtained. In a SUS reaction tube having an inner diameter of 35 mm, 50 mL of a nickel/diatomaceous earth catalyst with a column shape having a diameter of 5 mm and a length of 5 mm (nickel content: 50% by weight) was packed. The catalyst was reduced for activation at 200 C. under hydrogen gas flow. After cooling, hydrogen gas was introduced under pressure into the reaction tube. The pressure was kept constant at 4 MPa, and the catalyst layer temperature was kept at 100 C. under external heating. Then, hydrogen gas was supplied from the inlet of the reaction tube at a flow rate of 1.1 NL/h. While keeping the flow of hydrogen gas, the above crude xylylenediamine was supplied from the inlet of the reaction tube in a rate of 25.2 g/h, to conduct the re-hydrogenation continuously. The hydrogenation product solution and unreacted hydrogen gas were discharged from the outlet of the reaction tube. The discharged hydrogenation product solution was sampled and analyzed by a gas chromatography. The concentration of m-xylylenediamine was 91.7% by weight and the concentration of 3-cyanobenzylamine was less than the detection limit of 30 ppm by weight. After evaporating off liquid ammonia from the obtained hydrogenation product solution, the crude m-xylylenediamine was distilled under reduced pressure (125 C., 6 Torr). The concentration of m-xylylenediamine was 99.99% by weight and the concentration of 3-cyanobenzylamine was less than the detection limit of 30 ppm by weight. As described above, in the method of the present invention, the amount of the solvent containing liquid ammonia to be used is reduced while keeping high yields even when using a simple apparatus, to reduce the quantity of energy required for removing the solvent. Therefore, the present invention provides a cost-effective method of producing xylylenediamines by the hydrogenation of phthalonitriles. Thus, the present invention is of a great industrial value.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Aminomethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Kumano, Tatsuyuki; Shigematsu, Ryusuke; Kato, Kinji; Nakaya, Kenji; US2008/9654; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthetic Route of 10406-24-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10406-24-3, name is 3-(Aminomethyl)benzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 2 m-Cyanobenzylamine (13.2 g), sodium nitrite (10.4 g), and dimethylformamide (100 ml) were mixed together, and the mixture was vigorously stirred at room temperature. Trifluoroacetic acid (22.8 g) was added dropwise to the mixture over one hour. After completion of addition, the mixture was further allowed to react at 100 C. for one hour. For the subsequent process, the procedure of Example 1 was repeated, to thereby obtain 6.9 g of m-cyanobenzyl alcohol (bp. 128-130 C./400 Pa) (yield 52%). The purity of the product was 98%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Aminomethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Showa Denko K.K.; US6187945; (2001); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts