Category: 10282-32-3

Cp*Co(III) and Cu(OAc)₂ bimetallic catalysis for Buchwald-type C-N cross coupling of aryl chlorides and amines under base, inert gas & solvent-free conditions was written by Srivastava, Avinash K.;Sharma, Charu;Joshi, Raj K.. And the article was included in Green Chemistry in 2020.Formula: C14H12N2 This article mentions the following:

A strategy involving bimetallic catalysis with a combination of Cp*Co(CO)I₂ and Cu(OAc)₂ was used for performing Buchwald-type C-N coupling reactions of aryl chlorides RCl (R = Ph, pyridin-2-yl, 4-cyanophenyl, etc.) with amines R¹NHR² (R¹ = H, Et; R² = Pr, benzyl, 4-methoxyphenyl, etc.; R¹R² = -(CH₂)₄– and -(CH₂)₅-). The reactions proceeded at 100°C to produce excellent yields of many of the desired C-N coupled products R¹N(R)R², in 4 h, under aerobic reaction conditions. The reactions were shown to run under base-free and solvent-free conditions, enabling this strategy to work efficiently for electron-withdrawing and base-sensitive functionalities. The presented methodol. was found to be equally efficient for electron-donating functionalities as well as for primary (1°) and secondary (2°) aromatic and aliphatic amines. Moreover, the products were easily separated through the extractions of the organic aqueous layer, with this process chromatog. separations are not required. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Formula: C14H12N2).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Formula: C14H12N2

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Oxidation of alcohols by transition metal complexes. Part III. The reduction of aldimines by hydrogen transfer from propan-2-ol catalyzed by rhodium complexes was written by Grigg, Ronald;Mitchell, Thomas R. B.;Tongpenyai, Ngampong. And the article was included in Synthesis in 1981.Category: nitriles-buliding-blocks This article mentions the following:

Benzaldimines 4-RC₆H₄CH:NCH₂Ph (R = H, Me, MeO, Cl, CF₃) and I (R¹ = H, MeO, Cl, CF₃, cyano; R² = H, MeO, Cl, CF₃, cyano) reacted with Me₂CHOH and a Rh complex to yield the resp. 4-RC₆H₄CH₂NHCH₂Ph and II. A mixture of PhCH:NCH₂Ph, RhCl(PPh₃)₃, and Na₂CO₃ in Me₂CHOH was refluxed 60 min to give ∼90% (Ph₂CH₂)₂NH. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Category: nitriles-buliding-blocks).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Category: nitriles-buliding-blocks

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Ruthenium-Catalyzed Direct Reductive Amination in HCOOH/NEt₃ Mixture was written by Zhu, Mengping. And the article was included in Catalysis Letters in 2014.Reference of 10282-32-3 This article mentions the following:

Abstract: A one-pot direct reductive amination of aldehydes with primary and secondary amines using Noyori’s catalyst (η⁶-arene)Ru(H)TsDPEN in neat HCOOH/NEt₃ mixture has been developed. The catalyst formed in situ allows full conversion of aldehydes with high selectivities towards the desired amine products within hours or even minutes at room temperature For aromatic aldehydes, both 5:2 and 5:3 HCOOH/NEt₃ mixtures prove to be suitable reaction media, with the former affording higher selectivities while the latter leading to much faster reaction rates. For aliphatic aldehydes, the 5:3 HCOOH/NEt₃ mixture gives much higher selectivities due to the minimal loss from aldol condensation. This method has great application potential for the synthesis of amine products given the mild conditions. Graphical Abstract: [Figure not available: see full text.]. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Reference of 10282-32-3).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Reference of 10282-32-3

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Nitrile – Wikipedia,
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N-Alkylation of amines with alcohols over nanosized zeolite beta was written by Reddy, Marri Mahender;Kumar, Macharla Arun;Swamy, Peraka;Naresh, Mameda;Srujana, Kodumuri;Satyanarayana, Lanka;Venugopal, Akula;Narender, Nama. And the article was included in Green Chemistry in 2013.Formula: C14H12N2 This article mentions the following:

Direct N-alkylation of amines with alcs. was successfully performed by using nanosized zeolite beta, which showed the highest catalytic activity among other conventional zeolites. This method has several advantages, such as eco-friendliness, moderate to high yields, and simple work-up procedure. The catalyst was successfully recovered and reused without significant loss of activity and only water is produced as co-product. In addition, imines were also efficiently prepared from the tandem reactions of amines with 2-, 3- and 4-nitrobenzyl alcs. using nanosized zeolite beta. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Formula: C14H12N2).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Formula: C14H12N2

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

An Efficient Metal-Free Method for the Denitrosation of Aryl N-Nitrosamines at Room Temperature was written by Chaudhary, Priyanka;Korde, Rishi;Gupta, Surabhi;Sureshbabu, Popuri;Sabiah, Shahulhameed;Kandasamy, Jeyakumar. And the article was included in Advanced Synthesis & Catalysis in 2018.Related Products of 10282-32-3 This article mentions the following:

A simple and practical method for the denitrosation of aryl N-nitrosamines to secondary amines is reported under metal-free conditions using iodine and triethylsilane. Several reduction-susceptible functional groups such as alkene, alkyne, nitrile, nitro, aldehyde, ketone and ester are very stable during the denitrosation, which is remarkable. Broad substrate scope, room temperature reactions and excellent yields are the addnl. features of the current methodol. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Related Products of 10282-32-3).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Related Products of 10282-32-3

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Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Studies on the in vitro hepatic microsomal formation of amides during the metabolism of certain secondary and tertiary benzylic amines was written by Ulgen, M.;Gorrod, J. W.. And the article was included in European Journal of Drug Metabolism and Pharmacokinetics in 2000.Name: 4-(Benzylamino)benzonitrile This article mentions the following:

A review with 21 references Part of our interest during the last few years has been to investigate the possible intermediate(s) and mechanism(s) involved in the formation of amides from N-benzylic amines. A number of benzylic amines with different aryl and alkyl moieties introduced onto the constituent nitrogen were prepared, thus creating a wide variety of secondary, tertiary and heterocyclic benzylic amines with different logP and pKa characteristics (Tables I & II). In some experiments, the possible intermediates of this reaction, i.e. nitrones (Table III), imines (Table IV) and amides themselves (Table V), were used as substrates in our metabolic studies. Their in vitro hepatic microsomal metabolism was studied in order to obtain a structure/metabolic activity relationship for the formation of amides from benzylic amines. This communication reviews these studies and reports our conclusions as to the mechanism of formation of amides from N-benzylic amines. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Name: 4-(Benzylamino)benzonitrile).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Name: 4-(Benzylamino)benzonitrile

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Palladium-Catalyzed Amination of Aryl Nonaflates was written by Anderson, Kevin W.;Mendez-Perez, Maria;Priego, Julian;Buchwald, Stephen L.. And the article was included in Journal of Organic Chemistry in 2003.HPLC of Formula: 10282-32-3 This article mentions the following:

The first detailed study of the palladium-catalyzed amination of aryl nonaflates is reported. Use of ligands such as BINAP allows for the catalytic amination of electron-rich and -neutral aryl nonaflates with both primary and secondary amines. With use of Xantphos, the catalytic amination of a variety of functionalized aryl nonaflates resulted in excellent yields of anilines; even 2-carboxymethyl aryl nonaflate is effectively coupled with a primary alkylamine. Moderate yields were obtained when coupling halo-aryl nonaflates with a variety of amines, where in most cases the aryl nonaflate reacted in preference to the aryl halide. Overall, aryl nonaflates are an effective alternative to triflates in palladium-catalyzed C-N bond-forming processes due to their increased stability under the reaction conditions. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3HPLC of Formula: 10282-32-3).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.HPLC of Formula: 10282-32-3

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Nitrile – Wikipedia,
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Synthesis of Secondary Amines from One-Pot Reductive Amination with Formic Acid as the Hydrogen Donor over an Acid-Resistant Cobalt Catalyst was written by Jiang, Liang;Zhou, Peng;Zhang, Zehui;Jin, Shiwei;Chi, Quan. And the article was included in Industrial & Engineering Chemistry Research in 2017.Synthetic Route of C14H12N2 This article mentions the following:

Developing new heterogeneous non-noble metal catalysts to replace noble-metal catalysts in organic transformations is of high importance in modern synthetic chem. Herein, nitrogen-doped carbon embedded Co catalysts (abbreviated as Co@CN-T-AT, in which T represents the pyrolysis temperature, AT represents the acid-leaching process) were prepared through the simple pyrolysis of graphene oxide-supported cobalt-based zeolitic imidazolate-frameworks, followed by the acid-leaching process. The Co@CN-600-AT catalyst demonstrated the highest catalytic activity among the synthesized Co catalyst toward the reductive amination of carbonyl compounds with nitro compounds by transfer hydrogenation with formic acid as the hydrogen donor, which integrated three consecutive steps into a one-pot reaction. By applying this catalyst, structurally diverse secondary amines were produced in good to excellent yields without the reduction of other functional groups. The transfer hydrogenation of the imines (C=N bonds) was the rate-determining step. Furthermore, the catalyst was highly stable and could be reused without decrease of the catalytic activity. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Synthetic Route of C14H12N2).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Synthetic Route of C14H12N2

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N-Alkylation of Amines with Alcohols Catalyzed by a Water-Soluble Cp^*Iridium Complex: An Efficient Method for the Synthesis of Amines in Aqueous Media was written by Kawahara, Ryoko;Fujita, Ken-ichi;Yamaguchi, Ryohei. And the article was included in Advanced Synthesis & Catalysis in 2011.Product Details of 10282-32-3 This article mentions the following:

An efficient and environmentally benign catalytic system for the synthesis of various organic amines catalyzed by the water-soluble and air-stable (pentamethylcyclopentadienyl)-iridium-ammine iodide complex, [Cp^*Ir(NH₃)₃][I^–]₂, has been developed. A wide variety of secondary and tertiary amines were synthesized by the N-alkylation reactions of theor. equivalent of amines with alcs. in water under air without a base. The synthesis of cyclic amines was also achieved by the N-alkylation of benzylamine with diols. Furthermore, recycling of the present water-soluble Cp^*Ir catalyst was accomplished. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Product Details of 10282-32-3).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Product Details of 10282-32-3

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Nitrile – Wikipedia,
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A recyclable Cu/Al-HT catalyst for amination of aryl chlorides was written by Likhar, Pravin R.;Arundhathi, R.;Kantam, M. Lakshmi. And the article was included in Tetrahedron Letters in 2007.COA of Formula: C14H12N2 This article mentions the following:

A simple Cu/Al-HT catalyzed amination of aryl chlorides with primary and secondary aromatic amines was developed. This ligand-free heterogeneous Cu/Al-HT catalyst, in conjunction with base, also efficiently works for the amination of aryl chlorides with cycloalkyl amines. This method tolerates a variety of functional groups and does not require an expensive additive. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3COA of Formula: C14H12N2).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. COA of Formula: C14H12N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts