Synthetic Route of 1021871-35-1, A common heterocyclic compound, 1021871-35-1, name is 3-Chloro-5-(hydroxymethyl)benzonitrile, molecular formula is C8H6ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 4: 3-Chloro-5-cyanobenzyl carbonochloridate 3-Chloro-5-(hydroxymethyl)benzonitrile (25 g, 145 mmol) was dissolved in THF (200 mL). The resulting yellow solution was cooled to 10¡ã C. in an ice bath and treated dropwise with phosgene in toluene (152 mL, 289 mmol). The reaction mixture was stirred at ambient temperature for 16 hrs. The mixture was concentrated under reduced pressure and the crude material was diluted with toluene (200 ml) and re-concentrated under reduced pressure. The residue was purified by chromatography on silica (Redisep 340 g column on a Biotage system), eluting with EtOAc/iso-hexane to give 3-chloro-5-cyanobenzyl carbonochloridate as an oil. 1H NMR (600 MHz, CDCl3) delta 7.70 (1H, s), 7.66 (1H, s), 7.62 (1H, s), 5.32 (2H, s).
The synthetic route of 1021871-35-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Novartis AG; Legrand, Darren Mark; Furminger, Vikki; Thomson, Christopher; Hughes, Owen Rhys; Stanley, Emily; US2014/171403; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts