The important role of Ethyl 3-cyanopropanoate

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 3-cyanopropanoate, its application will become more common.

Synthetic Route of 10137-67-4,Some common heterocyclic compound, 10137-67-4, name is Ethyl 3-cyanopropanoate, molecular formula is C6H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a suspension of Zn powder (196 mg, 3 mmol) in THF (5 mL) weresuccessively added the appropriate nitrile (1 mmol), pure or dissolvedin a minimum amount of THF, and allyl bromide (0.26 mL, 3 mmol). The solution was heated rapidly to reflux and cooled down to rt after 10-15 min. Aq 1 M HCl (5 mL) was added and the aqueous layer was extracted with EtOAc (2 × 5 mL). The combined organic layers weresuccessively washed with aq 2 M NaOH and brine, dried (anhydMgSO4), and filtered. The solvents were removed in vacuo to affordthe crude product, which was purified by flash chromatography onsilica gel, only when required.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 3-cyanopropanoate, its application will become more common.