Category: 1013112-48-5

Meng, Xiang-He published the artcileNaN(SiMe3)2/CsTFA Copromoted Aminobenzylation/Cyclization of 2-Isocyanobenzaldehydes with Toluene Derivatives or Benzyl Compounds: One-Pot Access to Dihydroquinazolines and Quinazolines, Recommanded Product: 2-Formyl-4,5-dimethoxybenzonitrile, the main research area is dihydroquinazoline chemoselective preparation; isocyanobenzaldehyde toluene derivative aminobenzylation cyclization sodium bistrimethylsilylamide cesium trifluoroacetate; quinazoline chemoselective preparation; benzylbenzotriazole isocyanobenzaldehyde aminobenzylation cyclization sodium bistrimethylsilylamide cesium trifluoroacetate.

A NaN(SiMe3)2/CsTFA copromoted aminobenzylation/cyclization reaction of 2-isocyanobenzaldehydes with toluene derivatives or benzyl compounds to afford 4-benzylsubstitued dihydroquinazolines I [R1 = H, Me, OPh, etc.; Ar = Ph, 1-naphthyl, 4-NMe2, etc.] and quinazoline derivatives II [Ar1 = Ph, 4-MeOC6H4, 2-naphthyl] were developed. Further applications, including synthesis of quinazoline, dihydroindolo[1,2-c]quinazoline and dihydro-8H-isoquinolino[2,3-c]quinazoline, demonstrated the tremendous potential of the tandem reaction.

Journal of Organic Chemistry published new progress about Alkyl groups. 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Recommanded Product: 2-Formyl-4,5-dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Tingting published the artcileAsymmetric synthesis of α-(1-oxoisoindolin-3-yl)glycine: synthetic and mechanistic challenges, Application of 2-Formyl-4,5-dimethoxybenzonitrile, the main research area is oxoisoindolinyl glycine enantioselective synthesis crystal structure glycine Schiff base; cyanobenzaldehyde aldol reaction cyclization rearrangement conjugate addition.

We report herein that the NaOMe-catalyzed reactions between the chiral glycine Schiff base (S)-4 with 2-cyanobenzaldehyde provide for a convenient preparation of the novel α-(1-oxoisoindolin-3-yl)glycine of high pharmaceutical potential. The reactions involve at least eight synthetic steps and can mechanistically be realized only with application of Ni(II) complexes described in this study.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aldol addition. 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Application of 2-Formyl-4,5-dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Le, Thanh Nguyen published the artcileNovel synthesis of the natural protoberberine alkaloids: oxypalmatine and oxypseudopalmatine, Name: 2-Formyl-4,5-dimethoxybenzonitrile, the main research area is oxypalmatine oxypseudopalmatine protoberberine alkaloid synthesis cycloaddition nucleophilic substitution.

Oxypalmatine (I) and oxypseudopalmatine (II) were synthesized in three steps from the benzonitrile III and toluamides IV (R1 = OMe, R2 = H; R1 = H, R2 = OMe, resp.). The lithiated cycloaddition reaction yielded 3-arylisoquinolinone intermediates. A subsequent internal SN2 reaction produced the corresponding 8-oxoprotoberberines, oxypalmatine and oxypseudopalmatine.

Bulletin of the Korean Chemical Society published new progress about Cycloaddition reaction. 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Name: 2-Formyl-4,5-dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bert, Katrien published the artcileChiral imidate-ferrocenylphosphanes: synthesis and application as P,N-ligands in iridium(I)-catalyzed hydrogenation of unfunctionalized and poorly functionalized olefins, Application of 2-Formyl-4,5-dimethoxybenzonitrile, the main research area is chiral imidate ferrocenylphosphine ligand preparation iridium catalyzed hydrogenation olefin; asym hydrogenation unfunctionalized poorly functionalized olefin imidate ferrocenylphosphine iridium.

A small library of chiral imidate-ferrocenylphosphine ligands was efficiently synthesized (8 examples) and evaluated in the iridium(I)-catalyzed hydrogenation of unfunctionalized and poorly functionalized olefins. These catalysts perform very well in a range of examples (yields and ee’s up to 100%).

Organic & Biomolecular Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Application of 2-Formyl-4,5-dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hu, Jiaxing published the artcileTfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction, Formula: C10H9NO3, the main research area is regioselective arylisoindolinone preparation tandem reaction electron rich arene formylbenzonitrile; metal free trifluoromethanesulfonic acid catalyzed carbon hydrogen functionalization.

A convenient metal-free method for the synthesis of 3-aryl isoindolinones via TfOH catalyzed aromatic C-H functionalization of electron-rich arenes with 2-formylbenzonitriles is developed. This process provided a new efficient strategy for the synthesis of isoindolinone derivatives in good to high yields and regioselectivities by forming two bonds.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Formula: C10H9NO3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

More, Vijaykumar published the artcileThe first organocatalytic asymmetric synthesis of 3-substituted isoindolinones, Name: 2-Formyl-4,5-dimethoxybenzonitrile, the main research area is quinine cinchonidine urea thiourea alkaloid catalyst isoindolinone preparation.

Herein the authors describe the first asym. organocatalytic synthesis of 3-substituted isoindolinone derivatives by a convenient aldol-cyclization-rearrangement tandem reaction of malonates with 2-cyanobenzaldehyde. Bifunctional thiourea-cinchona catalysts proved to be particularly effective, giving the title compounds in high yield and moderate-to-good enantiomeric excesses. Moreover an efficient process of reverse crystallization led to a further enrichment up to >99% ee. The synthesis of the target compounds was achieved using N-[3,5-bis(trifluoromethyl)phenyl]-N’-[(8α,9S)-6′-methoxycinchonan-9-yl]thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N’-[(8α,9S)-cinchonan-9-yl]thiourea, etc. as catalysts in comparison with N-[3,5-bis(trifluoromethyl)phenyl]-N’-[(1R,2R)-2-(dimethylamino)cyclohexyl]thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N’-[(1S,2S)-2-(dimethylamino)-1-phenylpropyl]thiourea, cupreidine, etc. The title compounds thus formed included (-)-2-(2,3-dihydro-3-oxo-1H-isoindol-1-yl)-1,3-propanedioic acid 1,3-di-Me ester (I).

RSC Advances published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Name: 2-Formyl-4,5-dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bao, Wen published the artcileCopper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines, HPLC of Formula: 1013112-48-5, the main research area is cyanobenzaldehyde formylbenzonitrile cyclization isocyanoacetate copper catalyst; aminoisoquinoline isoquinolinamine preparation.

A Cu(acac)2-catalyzed cyclization reaction of 2-cyanobenzaldehydes with 2-isocyanoacetates was successfully developed providing an efficient strategy for the synthesis of substituted 1-aminoisoquinolines I (R1 = H, 6-Cl, 7-F, 8-MeO, etc.; R2 = CO2Et, CO2Me, CO2Bu-t). The reaction proceeded smoothly under mild conditions with high efficiency, and provides an alternative strategy for the synthesis of 1-aminoisoquinoline containing mols.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, HPLC of Formula: 1013112-48-5.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kobayashi, Kazuhiro published the artcileA Convenient Synthesis of 2,3-Dihydro-3-methylidene-1H-isoindol-1-ones by Reaction of 2-Formylbenzonitriles with Dimethyloxosulfonium Methylide, Quality Control of 1013112-48-5, the main research area is formyl benzonitrile dimethyloxosulfonium methylide heterocyclization; dihydro methylidene isoindolone preparation.

A facile method for the synthesis of 2,3-dihydro-3-methylidene-1H-isoindol-1-one and its derivatives carrying substituent(s) at C(5) and/or C(6) has been developed. The reaction of 2-formylbenzonitrile with dimethyloxosulfonium methylide, generated by the treatment of trimethylsulfoxonium iodide with NaH in DMSO/THF at 0°, resulted in the formation of 2,3-dihydro-3-methylidene-1H-isoindol-1-one (I) in 77% yield. Similarly, six 2-formylbenzonitriles carrying substituent(s) at C(4) and/or C(5), also gave the corresponding expected products in comparable yields.

Helvetica Chimica Acta published new progress about Aryl aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (o-cyano). 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Quality Control of 1013112-48-5.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts