Category: 101219-69-6

Asymmetric Reduction of Ketones by Phosphoric Acid Derived Catalysts was written by Zhang, Zuhui;Jain, Pankaj;Antilla, Jon C.. And the article was included in Angewandte Chemie, International Edition in 2011.Related Products of 101219-69-6 This article mentions the following:

Asym. reduction of ketones using a phosphoric acid derivative as the precatalyst was reported. Using catecholborane as a reducing agent, chiral secondary alcs. were produced with high levels of enantioselectivities over a resonably broad substrate scope. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Related Products of 101219-69-6).

(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C閳ユ弲 bond formation or by dehydration of primary carboxamides. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Related Products of 101219-69-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Regioselective Hydration of Terminal Alkynes Catalyzed by a Neutral Gold(I) Complex [(IPr)AuCl] and One-Pot Synthesis of Optically Active Secondary Alcohols from Terminal Alkynes by the Combination of [(IPr)AuCl] and Cp*RhCl[(R,R)-TsDPEN] was written by Li, Feng;Wang, Nana;Lu, Lei;Zhu, Guangjun. And the article was included in Journal of Organic Chemistry in 2015.SDS of cas: 101219-69-6 This article mentions the following:

A neutral gold(I) complex [(IPr)AuCl] [IPr = 1,3-bis(diisopropylphenyl)imidazol-2-ylidene] was found to be a highly effective catalyst for the hydration of terminal alkynes, including aromatic alkynes and aliphatic alkynes. The desired Me ketones were obtained in high yields with complete regioselectivities. Furthermore, a series of optically active secondary alcs. could be obtained in high yield with good to excellent enantioselectivities via one-pot sequential hydration/asym. transfer hydrogenation (ATH) from terminal alkynes by the combination of of [(IPr)AuCl] and Cp*RhCl[(R,R)-TsDPEN] [Cp* = pentamethylcyclopentadienyl, TsDPEN = N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine]. Notably, this research exhibited the potential of the direct use of neutral gold(I) complexes instead of cationic ones as catalysts for the activation of multiple bonds for organic synthesis. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6SDS of cas: 101219-69-6).

(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.SDS of cas: 101219-69-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Core-shell structured mesoporous silica: a new immobilized strategy for rhodium catalyzed asymmetric transfer hydrogenation was written by Zhang, Huaisheng;Jin, Ronghua;Yao, Hui;Tang, Shuang;Zhuang, Jinglan;Liu, Guohua;Li, Hexing. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2012.Reference of 101219-69-6 This article mentions the following:

A core-shell structured heterogeneous rhodium catalyst exhibited excellent catalytic activity and enantioselectivity in asym. transfer hydrogenation of aromatic ketones in aqueous medium, which could be recovered easily and used repetitively twelve times without affecting obviously its enantioselectivity. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Reference of 101219-69-6).

(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Reference of 101219-69-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Side chain hydroxylation of aromatic compounds by fungi. 1. Products and stereochemistry was written by Holland, Herbert L.;Bergen, Eleanor J.;Chenchaiah, P. Chinna;Khan, Shaheer H.;Munoz, Benito;Ninniss, Ronald W.;Richards, Denise. And the article was included in Canadian Journal of Chemistry in 1987.Synthetic Route of C9H9NO This article mentions the following:

The fungus Mortierella isabellina can convert ethylbenzene and a number of para-substituted derivatives to the corresponding optically active 1-phenylethanols with enantiomeric excesses between 5% and 40% and chem. yields up to 45%. 2-Ethylnaphthalene, 2-ethylthiophene, and n-propylbenzene were similarly converted, as were the bicyclic compounds indane and tetralin. In most cases, the R absolute configuration of product predominated. The fungi Cunninghamella echinulata elegans and Helminthosporium species are also capable of performing some of these transformations. M. isabellina And C. elegans also produce 2-phenylethanols as products in some cases. The highest enantiomeric excesses during benzylic hydroxylation were obtained with Helminthosporium and are attributable, at least in part, to further stereoselective oxidation of the alchol. Cross-induction experiments with M. isabellina indicate that the same enzyme may be responsible for the benzylic hydroxylation of ethylbenzene, 2-ethylthiophene, and 2-ethylnaphthalene. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Synthetic Route of C9H9NO).

(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Synthetic Route of C9H9NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

An ion-pair immobilization strategy in rhodium-catalyzed asymmetric transfer hydrogenation of aromatic ketones was written by Xu, Yulong;Cheng, Tanyu;Long, Jie;Liu, Ketang;Qian, Qingqian;Gao, Fei;Liu, Guohua;Li, Hexing. And the article was included in Advanced Synthesis & Catalysis in 2012.Related Products of 101219-69-6 This article mentions the following:

A chiral diamine-based homogeneous cationic rhodium catalyst was developed and two heterogeneous cationic rhodium catalysts were obtained via the encapsulation of the homogeneous cationic rhodium catalyst within Me-SBA-15 and Me-SBA-16. All these catalysts presented excellent catalytic activities and high enantioselectivities in ultrasound-promoted asym. transfer hydrogenation of aromatic ketones and represent a successful use of the ion-pair immobilization strategy. More importantly, the encapsulation of the cationic rhodium functionality within Me-SBA-16 had an obvious high recyclability, in which the recycled catalyst could be reused nine times without significantly affecting its enantioselectivity, showing good potential in industrial application. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Related Products of 101219-69-6).

(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Related Products of 101219-69-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Enantioselective catalytic reduction of ketones using C₂-symmetric diamines as chiral ligands was written by Gamez, Patrick;Fache, Fabienne;Mangeney, Pierre;Lemaire, Marc. And the article was included in Tetrahedron Letters in 1993.Quality Control of (R)-4-(1-Hydroxyethyl)benzonitrile This article mentions the following:

The catalytic enantioselective reduction of various prochiral ketones is reported using C₂-sym. diamines as ligands. Up to 99% e.e. at 100% conversion are obtained. In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Quality Control of (R)-4-(1-Hydroxyethyl)benzonitrile).

(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Quality Control of (R)-4-(1-Hydroxyethyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts