Category: 101184-73-0

Application of 101184-73-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 101184-73-0, name is 2-(4-Bromophenyl)-2-methylpropanenitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2-(4-Bromophenyl)-2-methylpropylamine Prepared from alpha,alpha-dimethyl-(4-bromo)phenylacetonitrile (16 g, 0.0676 mol) using the method of description 4 to afford the title compound as the hydrochloride salt (16.87 g, 89%). 1H NMR (CDCI3) delta: 1.23 (6H, s), 2.89 (2H, s), 7.27 (2H, d, J=9 Hz), 7.43 (2H, d, J=9 Hz), 7.77 (3H, br s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Bromophenyl)-2-methylpropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SmithKline Beecham p.l.c.; US6358974; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 101184-73-0, name is 2-(4-Bromophenyl)-2-methylpropanenitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 101184-73-0

To degassed toluene (200 mL) was added palladium acetate (0.30 g, 1.3 mmol) and x-phos (1.3 g, 2.7 mmol) and the mixture degassed a further 5 minutes. To the reaction mixture was then added cesium carbonate (35.0 g, 107 mmol), beta alanine ethyl ester hydrochloride (6.2 g, 40.4 mmol) and 2-(4-bromophenyl)-2-methylpropanenitrile (6.0 g, 26.8 mmol). The reaction mixture was heated at reflux for 2 hours, cooled and filtered through celite. Filtrate concentrated and the residue further purified on silica eluding with 25% ethyl acetate in heptane to give ethyl 3-(4-(2-cyanopropan-2-yl)phenylamino)propanoate (4.05 g, 58%) as a yellow solid. 1H NMR (300 MHz, CDCl3): delta ppm 1.26 (t, 3H), 1.66 (s, 6H), 2.60 (t, 2H), 3.44 (t, 2H), 4.15 (q, 2H), 4.18 (br s, 1H), 6.61 (d, 2H), 7.26 (d, 2H).

The synthetic route of 101184-73-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; pfizer Inc; US2010/197591; (2010); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 101184-73-0, The chemical industry reduces the impact on the environment during synthesis 101184-73-0, name is 2-(4-Bromophenyl)-2-methylpropanenitrile, I believe this compound will play a more active role in future production and life.

Reference Example 30b 2,2-Dimethyl-(4-[Furan-2-yl]-Phenyl)-Acetonitrile. Using essentially the same procedure as in reference example 30a, except using 2-(4-Bromo-phenyl)-2-methyl-propionitrile (reference example 31b). 1H NMR (CDCl3) d 1.74 (s, 6H), 6.47 (dd, J=2, 1 Hz, 1H), 6.66 (d, J=2 Hz, 1H), 7.47 (m, 3H), 7.68 (m, 2H),. MS (EI) m/z 211 (M)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Bromophenyl)-2-methylpropanenitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Aventis Pharmaceuticals Inc.; US6541505; (2003); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 101184-73-0, name is 2-(4-Bromophenyl)-2-methylpropanenitrile, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 101184-73-0

A suspension of 2-(4-bromophenyl)-2-methylpropanenitrile (110 mg, 0.491 mmol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (187 mg, 0.736 mmol), potassium acetate (72.3 mg, 0.736 mmol) and Pd(dppf)Cl2 (18.0 mg, 0.0250 mmol) in dioxane (3 mL) was degassed and the reaction was heated to 95 C. for 90 minutes. The reaction mixture was concentrated to provide 2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanenitrile which was used directly in subsequent reactions.

According to the analysis of related databases, 101184-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Gilead Scientific Systems, Inc.; Cory, Kevin S; Doo, Jimin; Farrand, Julie; Guerrero, Juan A; Katana, Ashley A; Cato, Daryl; Laisaweed, Scott I; Lee, Jiayao; Lingco, John O; Nicolaus, May; Notte, Gregory; Phyen, Hyeoung-Jung; Sangy, Michael; Sumit, Arun C; Adam J, Surayyah; Stephens, Cork L; Venkatraman, Chandrasekar; Watkins, William J; Yang, Jong Yu; Jabloki, Jeff; Jifel, Shiela; Ro, Jennifer; Lee, Sung H; Jao, Chung Dong; Grove, Jeffery; Su, Jianjun; Blomgren, Peter; Mitchell, Scott A; Shyung, Jin Ming; Chandrasekar, Jayaraman; (460 pag.)KR2016/37198; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 101184-73-0, name is 2-(4-Bromophenyl)-2-methylpropanenitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H10BrN

To a stirred solution of 2-(4-bromophenyl)-2-methylpropanenitrile (11.88 g, 53.0 mmol, 1.0 eq.) in THF (150 ml) was added dropwise a solution of B in THF (1.0 N, 159 ml, 159.0 mmol, 3.0 eq.) at an ice-water bath temperature, and the resultant mixture was heated to reflux for 4 hours. The reaction mixture was cooled to ambient temperature, and was concentrated to dryness. The obtained residue was dissolved in methanol, and was heated to reflux for additional (0135) 1 hour. The reaction mixture was concentrated to dryness again, and was treated with water. The aqueous phase was extracted with EA, washed with brine, dried over Na2S04, and was concentrated to dryness. The crude material 2-(4-bromophenyl)-2-methylpropan- 1 -amine was used directly in next step without further purification

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PHARMABLOCK SCIENCES (NANJING), INC.; LIU, Liu; LI, Jin; YANG, Minmin; (126 pag.)WO2019/173804; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts