Category: 1009-35-4

Adding a certain compound to certain chemical reactions, such as: 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1009-35-4, Recommanded Product: 4-Fluoro-3-nitrobenzonitrile

General procedure: Before each run, the system (see Fig.4) was allowed to equilibrate by pumping solvent through for 30min with the Tube-in-Tube device at 16bar of hydrogen. An omnifit cartridge (20.0mm OD, 15.0mm ID) containing 1g of Pd-C catalyst was used. To avoid an overpressure of the system in the event of blockage, the upper pressure cut-off limit on the Knauer pump was set to 25bar. With the injection loop disconnected from the flow line, the loop was opened and filled manually (using a syringe) with 3.6mL of a 0.076M solution of starting material in ethanol (excess starting material solution exiting the loop was recovered for reuse). The injection loop was then closed off and switched into the flow stream. The outlet from the system (downstream of the back-pressure regulator) was collected for 120min. The solvent was removed under reduced pressure (using a rotary evaporator followed by a 2-stage rotary vane pump) to afford the product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-3-nitrobenzonitrile, and friends who are interested can also refer to it.

Reference:
Article; Dimitriou, Eleni; Jones, Richard H.; Pritchard, Robin G.; Miller, Gavin J.; O’Brien, Matthew; Tetrahedron; vol. 74; 47; (2018); p. 6795 – 6803;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some common heterocyclic compound, 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, molecular formula is C7H3FN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H3FN2O2

To a solution of 4-fluoro-3-nitrobenzonitrile (300 mg) and dimethyl malonate (286 mg) in DMF was added 60percent NaH at 0°C, followed by reaction at room temperature to obtain dimethyl (4-cyano-2-nitrophenyl)malonate (198 mg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1009-35-4, its application will become more common.

Reference:
Patent; Astellas Pharma Inc.; EP2003132; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1009-35-4 as follows. SDS of cas: 1009-35-4

4-Fluoro-3-nitrobenzonitrile (182.6 g; 1.10 moles) was dissolved in DMF at 25- 30°C under nitrogen atmosphere and sodium carbonate (249.8 g; 2.36 moles) was added. The slurry was heated to 45-50°C and compound obtained in example- 05/DMF solution (327.12 g; 0.78 moles) was added in 30-60 min at 45-50°C. The reaction mass was maintained for ~8h at 45-50°C. After completion of the reaction by HPLC, reaction mass was diluted with ethyl acetate and water at < 50°C and stirred for 30-45 min. Layers were separated and aqueous layer was extracted with ethyl acetate. Combined organic layer was washed with -10percent w/v brine solution and concentrated under vacuum at < 55°C. Methanol was added to the concentrated residue and heated to 45-50°C and stirred for lh at 45-50°C. The obtained slurry was cooled to 25-30°C and maintained for lh at 25-30°C. The product was filtered and washed with methanol followed by water and then dried under vacuum to obtain the title product as a light yellow wet solid (369.2 g; 74.85percent of theory on dried basis). HPLC Purity: 95.91percent. According to the analysis of related databases, 1009-35-4, the application of this compound in the production field has become more and more popular. Reference:
Patent; NATCO PHARMA LIMITED; APPAYE KALIYAPERUMAL, Srinivasan; TALASANI, Shyam Sunder Reddy; SAMATHAM, Nagalingam; KONDURI, Srinivasa Krishna Murthy; BUDIDETI, Shankar Reddy; MUDDASANI, Pulla Reddy; NANNAPANENI, Venkaiah Chowdary; (22 pag.)WO2019/38779; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Quality Control of 4-Fluoro-3-nitrobenzonitrile

Potassium hexamethyldisilazane [0.5 M in toluene] (12.04 mL, 24.08 mmol) was added to a solution of isopropanol (0.921 mL, 12.04 mmol) in tetrahydrofuran (20 mL) at 0° C. and stirred for 10 minutes. The resulting solution was added dropwise to a solution of commercially available 4-fluoro-3-nitrobenzonitrile at room temperature and stirred for several hours. Water was added and the product was extracted with ethyl acetate, dried with sodium sulfate and evaporated in vacuo to give the title compound

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1009-35-4, HPLC of Formula: C7H3FN2O2

The intermediate E lot used in this Example existed as ~3: 1 S:R mixture of phenyl chirality. To a vial charged with (S)-3-((lr,4S)-4-aminocyclohexyl)-5,5- dimethyl-4-phenyloxazolidin-2-one (0.150 g, 0.520 mmol) were added ACN (1.734 mL), TEA (0.145 mL, 1.040 mmol) and 4-fluoro-3-nitrobenzonitrile (commercially available from Alfa Aesar, Ward Hill, MA) (0.086 g, 0.520 mmol) respectively. The resulting orange solution was shaken at 80°C overnight. The resulting mixture was dried under reduced pressure and the material thus obtained was purified with a 25 g SNAP column ramping EtOAc in heptane from 0 – 100percent with 10percent DCM throughout providing 4-(((l S,4r)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3- yl)cyclohexyl)amino)-3-nitrobenzonitrile (0.172 g, 0.396 mmol, 76 percent yield) as a yellow solid. H NMR (400 MHz, CDC13) delta = 8.47 (d, J= 2.0 Hz, 1 H), 8.25 (d, J= 7.4 Hz, 1 H), 7.58 – 7.51 (m, 1 H), 7.47 – 7.28 (m, 4 H), 7.14 (br. s., 1 H), 6.85 (d, J = 9.2 Hz, 1 H), 4.39 (s, 1 H), 3.50 – 3.33 (m, 2 H), 2.24 – 2.06 (m, 3 H), 2.02 – 1.93 (m, 1 H), 1.90 – 1.79 (m, 1 H), 1.62 – 1.49 (m, 4 H), 1.47 – 1.26 (m, 2 H), 0.92 (s, 3 H). m/z (ESI) 435.2 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-3-nitrobenzonitrile, and friends who are interested can also refer to it.

Electric Literature of 1009-35-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 4-fluoro-3-nitrobenzonitrile (5.0 g, 30.1 mmol) and Fe powder (5.05 g, 90.3 mmol) in AcOH (100 mL) was heated at 80 C. for 1 hour under N2. Then the solvent was removed under vacuum and water (200 mL) was added to the residue. The solution was adjusted to pH 6 by addition of Na2CO3 and extracted with DCM (2×200 mL). The organic layers were combined, dried over Na2SO4, filtered and concentrated to yield 3-amino-4-fluorobenzonitrile (48), which was used without further purification. MS m/z 137.0 (M+1)+.; To a stirring suspension of imidazo[1,2-a]pyridine-3-carboxylic acid (1) (3.0 g, 18.5 mmol) in anhydrous dichloromethane (50 mL) at 0 C. was added dropwise oxalyl chloride (4.84 mL, 55.5 mmol). Then, three drops of anhydrous DMF was added and the reaction mixture was stirred at room temperature for 15 minutes. The solvent was concentrated and the crude solid was added to a stirring solution of 3-amino-4-fluorobenzonitrile (48) (2.5 g, 18.5 mmol) in anhydrous pyridine (50 mL) at room temperature. The reaction was stirred for 20 minutes and quenched with water (200 mL) with stirring for another 10 minutes. Then the precipitate was filtered and dried in air to yield N-(5-cyano-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide (49). 1H NMR (400 MHz, d6-DMSO) delta 10.40 (s, 1H), 9.43 (td, J=1.2, 6.8 Hz, 1H), 8.63 (s, 1H), 8.21 (dd, J=2.0, 7.2 Hz, 1H), 7.78-7.84 (m, 2H), 7.54-7.63 (m, 2H), 7.22 (dt, J=1.2, 6.8, 1H). MS m/z 281.1 (M+1)+.; NH2OH (10 mL, 32.1 mmol) was added in one portion to a stirred suspension of N-(5-cyano-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide (49) (3.6 g, 12.85 mmol) in EtOH (100 mL). The resulting suspension was heated at 70 C. for 3 hours and then the solvent was removed to yield N-(2-fluoro-5-(N?-hydroxycarbamimidoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide (50). 1H NMR (400 MHz, d6-DMSO) delta 10.21 (s, 1H), 9.70 (s, 1H), 9.45 (td, J=1.2, 7.2 Hz, 1H), 8.61 (s, 1H), 7.95 (dd, J=2.4, 7.6 Hz, 1H), 7.79 (td, J=1.2, 8.8 Hz, 1H), 7.51-7.60 (m, 2H), 7.31-7.37 (m, 1H), 7.19 (dt, J=1.2, 6.8, 1H), 5.88 (s, 2H). MS m/z 314.1 (M+1)+.

The chemical industry reduces the impact on the environment during synthesis 4-Fluoro-3-nitrobenzonitrile. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Product Details of 1009-35-4

A mixture of 4-fluoro-3-nitrobenzonitrile (1 .0 g; 6.02 mmol), 0.502 ml (6.62 mmol) of 3- amino-propan-1 -ol and 1 .15 ml (6.62 mmol) of diisopropylethylamine in 5 ml THF is stirred at rt for 1 hr (temperature raises somewhat at the beginning). After concentration in vacuo the residue is dissolved in 50 ml of ethyl acetate, washed with 50 ml of 4percent aqueous sodium hydrogen carbonate and brine, dried and concentrated. 1 .32 g of pure title compound as a solid are thus obtained (99 percent yield).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C7H3FN2O2

4-Fluoro-3-nitrobenzonitrile (1) (2 g, 0.012 mol) in ethyl acetate(50 mL) was supplemented with stannous chloride (11.4 g,0.06 mol). The reaction mixture was stirred for 30 min and then a saturated solution of sodium hydrogenocarbonate (100 mL) was added. This mixture was treated with ethyl acetate (300 mL) andthe aqueous layer was separated. The ethyl acetate layer was evaporated under reduced pressure. The crude product was dissolved in methanol, and ice was added; the resulting precipitate was collected by filtration (Yield: 30e60%).

The synthetic route of 1009-35-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bambi-Nyanguile, Sylvie-Mireille; Hanson, Julien; Ooms, Annie; Alpan, Lutfiye; Kolh, Philippe; Dogne, Jean-Michel; Pirotte, Bernard; European Journal of Medicinal Chemistry; vol. 65; (2013); p. 32 – 40;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Related Products of 1009-35-4, The chemical industry reduces the impact on the environment during synthesis 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, I believe this compound will play a more active role in future production and life.

Step l:4-(2-Hydroxy-ethoxy)-3-nitro-benzonitrile (3_28_2) [00222] Sodium (1.038 g, 45.2 mmol) was added to a mixture of ethylene glycol (28.03 g, 0.451 mol) in tetrahydrofuran (20 mL) at room temperature. After all sodium was consumed, 4-fluoro-3-nitro-benzonitrile 3_28_1 (5.0 g, 30.1 mmol) in tetrahydrofuran (10 mL) was added at -10¡ãC and the reaction mixture was stirred at room temperature for 3 hours. The reaction mixture was quenched by adding ice- water and neutralized to pH 7 using dilute hydrochloric acid at 0¡ãC. The mixture was extracted with ethyl acetate and the extract was washed with brine, dried over sodium sulfate and concentrated to dryness. The residue was purified by crystallization from ethyl acetate/hexanes to give the desired product (4.45 g, 71 percent yield) as a light yellow solid. [00223] NM (400 MHz, DMSO-d6): delta = 3.60-3.79 (m, 2H), 4.17-4.37 (m, 2H), 4.94 (t, J = 5.3 Hz, 1H), 7.56 (d, J = 8.8 Hz, 1H), 8.09 (dd, J = 8.9, 2.2 Hz, 1H), 8.45 (d, J = 2.0 Hz, 1H). [00224] MS (ES ) m/z: [M-H]’ calcd for C9H7N2O4: 207.18. Found: 206.90.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluoro-3-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AICURIS GMBH & CO. KG; KLENKE, Burkhard; WIEGAND, Irith; SCHIFFER, Guido; BROETZ-OESTERHELT, Heike; MAITI, Samarendra N.; KHAN, Jehangir; REDDY, Andhe; YANG, Zhixiang; HENA, Mostafa; JIA, Guofeng; LIGONG, Ou; LIANG, Hong; YIP, Judy; GAO, Chuanjun; TAJAMMUL, Sabiha; MOHAMMAD, Rahim; BISWAJEET, Ganguli; WO2013/110643; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reference of 1009-35-4, A common heterocyclic compound, 1009-35-4, name is 4-Fluoro-3-nitrobenzonitrile, molecular formula is C7H3FN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Before each run, the system (see Fig.4) was allowed to equilibrate by pumping solvent through for 30min with the Tube-in-Tube device at 16bar of hydrogen. An omnifit cartridge (20.0mm OD, 15.0mm ID) containing 1g of Pd-C catalyst was used. To avoid an overpressure of the system in the event of blockage, the upper pressure cut-off limit on the Knauer pump was set to 25bar. With the injection loop disconnected from the flow line, the loop was opened and filled manually (using a syringe) with 3.6mL of a 0.076M solution of starting material in ethanol (excess starting material solution exiting the loop was recovered for reuse). The injection loop was then closed off and switched into the flow stream. The outlet from the system (downstream of the back-pressure regulator) was collected for 120min. The solvent was removed under reduced pressure (using a rotary evaporator followed by a 2-stage rotary vane pump) to afford the product.

The synthetic route of 1009-35-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Dimitriou, Eleni; Jones, Richard H.; Pritchard, Robin G.; Miller, Gavin J.; O’Brien, Matthew; Tetrahedron; vol. 74; 47; (2018); p. 6795 – 6803;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts