1000339-52-5 Archives - Nitriles-buliding-blocks

Simple exploration of 3-Fluoro-2-nitrobenzonitrile

The synthetic route of 3-Fluoro-2-nitrobenzonitrile has been constantly updated, and we look forward to future research findings.

Related Products of 1000339-52-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1000339-52-5, name is 3-Fluoro-2-nitrobenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of fluorine substituted 2-nitrobenzonitrile (18.06 mmol, 3 g) in DMF (50 mL) was added 1-Boc-piperazine (36.12 mmol, 6.727 g) and K2CO3 (18.06 mmol, 2.496 g), and the mixture solution was stirred for 5 h at 160 C. The mixture was extracted with DCM. The organic layer was separated and dried over Na2SO4. Removal of the solvent produced a residue which was purified using column chromatography, eluted with a mixture of MeOH:CH2Cl2 (1:30, v:v), to afford intermediate 7a-1, 7c-1.

The synthetic route of 3-Fluoro-2-nitrobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Article; Liu, Wenwen; Wang, Huan; Li, Xiaokang; Xu, Yixiang; Zhang, Jian; Wang, Wei; Gong, Qi; Qiu, Xiaoxia; Zhu, Jin; Mao, Fei; Zhang, Haiyan; Li, Jian; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3117 – 3125;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Brief introduction of 3-Fluoro-2-nitrobenzonitrile

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1000339-52-5, its application will become more common.

Some common heterocyclic compound, 1000339-52-5, name is 3-Fluoro-2-nitrobenzonitrile, molecular formula is C7H3FN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: nitriles-buliding-blocks

Synthesis of 3-((3,4-dimethylphenyl)amino)-2-nitrobenzonitrile 3,4-Dimethylaniline (4.4 g, 36.1 mmol) was added into THF (60 mL). Sodium hydride (1.1 g, 45.2 mmol) was added and stirred for 1 hour. 3-Fluoro-2-nitrobenzonitrile (5 g, 30.1 mmol) was added and stirred for about 16 hours at room temperature. Water (2 mL) was added to quench the unreacted sodium hydride. The solvent was then evaporated and the residue was then purified by column chromatography using THF:hexane (1:4, v/v) as the eluent. 6.5 g (81% yield) of a red solid was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1000339-52-5, its application will become more common.

Reference:
Patent; Universal Display Corporation; KWONG, Raymond; LAM, Sze Kui; LAM, Siu Tung; TSANG, Kit Yee; LEE, Chi Hang; SZIGETHY, Geza; (159 pag.)US2016/218303; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Introduction of a new synthetic route about C7H3FN2O2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-2-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 1000339-52-5, name is 3-Fluoro-2-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1000339-52-5, Quality Control of 3-Fluoro-2-nitrobenzonitrile

A solution of 3-fluoro-2-nitrobenzonitrile (300 mg, 1 .806 mmol), 2-(tert-butoxy)ethan-1 – amine (233 mg, 1 .987 mmol), and N,N-diisopropylethylamine (0.379 mL, 2.167 mmol) in DMF (20mL) was stirred for 16 hours. The reaction was concentrated, and the resulting residue was purified via silica gel chromatography (0% to 40% EtOAc/hexanes) to afford 3- ((2-(tert-butoxy)ethyl)amino)-2-nitrobenzonitrile (450 mg) as a orange solid. LC-MS (ES) m/z = 264 [M+H]+. NMR (400 MHz, CDCI3): delta 8.39 (br. s., 1 H), 7.49 (dd, J = 7.1 , 8.9 Hz, 1 H), 7.19 (dd, J = 1 .0, 8.9 Hz, 1 H), 7.14 (dd, J = 1 .1 , 7.2 Hz, 1 H), 3.63 – 3.82 (m, 2H), 3.48 (q, J = 5.1 Hz, 2H), 1 .29 (s, 9H).

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; MEDINA, Jesus Raul; TIAN, Xinrong; NG DI MARCO, Christina; GRAYBILL, Todd L.; HEERDING, Dirk A.; LI, William Hoi Hong; MANGATT, Biju; MARTYR, Cuthbert D.; RIVERO, Raphael Anthony; (570 pag.)WO2019/49061; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Some scientific research about C7H3FN2O2

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Fluoro-2-nitrobenzonitrile, and friends who are interested can also refer to it.

Synthetic Route of 1000339-52-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1000339-52-5 name is 3-Fluoro-2-nitrobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of 3-([1,1?-biphenyl]-3-ylamino)-2-nitrobenzonitrile Biphenylamine (4.6 g, 27 mmol) and 3-fluoro-2-nitrobenzonitrile (5.0 g, 30.1 mmol) was added into THF (20 mL) and N,N-diisopropylethylamine (20 mL) and heated at 85 C. for 2 days. The solvent was then evaporated and the residue was then purified by column chromatography using THF:hexane (1:4, v/v) as the eluent. 7.0 g (82% yield) of a red solid was obtained.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Fluoro-2-nitrobenzonitrile, and friends who are interested can also refer to it.

Extracurricular laboratory: Synthetic route of 1000339-52-5

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1000339-52-5.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1000339-52-5, name is 3-Fluoro-2-nitrobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 1000339-52-5

Synthesis of 2-nitro-3-(phenylamino)benzonitrile Aniline (2.75 mL, 30.1 mmol) was added into THF (60 mL). Sodium hydride (0.867 g, 36.1 mmol) was added and stirred for 1 hour. 3-Fluoro-2-nitrobenzonitrile (5 g, 30.1 mmol) was added and stirred for about 16 hours at room temperature. Water (2 mL) was added to quench the unreacted sodium hydride. The solvent was then evaporated and the residue was then purified by column chromatography using THF:hexane (1:4, v/v) as the eluent. 6.0 g (83% yield) of a red solid was obtained.

The important role of 1000339-52-5

The synthetic route of 1000339-52-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1000339-52-5, name is 3-Fluoro-2-nitrobenzonitrile, A new synthetic method of this compound is introduced below., category: nitriles-buliding-blocks

Synthesis of 3-((3,5-dimethylphenyl)amino)-2-nitrobenzonitrile To 3,5-dimethylaniline (3.9 g, 32.2 mmol) in THF (90 mL) was added sodium hydride (95% in mineral oil, 1.23 g, 48.9 mmol) and stirred for 1 hour. 3-Fluoro-2-nitrobenzonitrile (4.3 g, 25.9 mmol) was added and the reaction mixture was heated to reflux for about 16 hours. Reaction mixture cooled to room temperature, then water was added and filtered through silica gel, washed with 5% THF in hexane and concentrated in vacuo. The crude mixture was purified by flash column chromatography with 10% THF in hexane to give orange powder which was recrystallised with 10% 1,2-dimethoxyethane in hexane to give 3-((3,5-dimethylphenyl)amino)-2-nitrobenzonitrile (3.8 g, 55% yield) as an orange powder.

The synthetic route of 1000339-52-5 has been constantly updated, and we look forward to future research findings.

Brief introduction of 1000339-52-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Fluoro-2-nitrobenzonitrile, its application will become more common.

Electric Literature of 1000339-52-5,Some common heterocyclic compound, 1000339-52-5, name is 3-Fluoro-2-nitrobenzonitrile, molecular formula is C7H3FN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis of 2-nitro-2-(tolylamino)benzonitrile o-Toluidine (2.75 g, 29 mmol) and 3-fluoro-2-nitrobenzonitrile (4.5 g, 27.1 mmol) was added into THF (20 mL) and N,N-diisopropylethylamine (20 mL) and heated at 85 C. for 2 days. The solvent was then evaporated and the residue was then purified by column chromatography using THF:hexane (1:4, v/v) as the eluent. 4.5 g (67% yield) of a red solid was obtained.