Category: 100-70-9

Lebedev, Yury published the artcileAsymmetric Hydroboration of Heteroaryl Ketones by Aluminum Catalysis, Recommanded Product: Picolinonitrile, the main research area is heterocyclic ketone enantioselective hydroboration aluminum catalyst; aluminum binol complex catalyst mechanism computational study.

A series of Me aluminum complexes bearing chiral biphenol-type ligands were found to be highly active catalysts in the asym. reduction of heterocyclic ketones (S/C = 100 – 500, ee up to 99%). The protocol is suitable for a wide range of substrates and has a high tolerance to functional groups. The formed 2-heterocyclic-alcs. are valuable building blocks in drug discovery or can be used as ligands in asym. catalysis. Isolation and comprehensive characterization of the reaction intermediates support a catalysis cycle proposed by DFT calculations

Journal of the American Chemical Society published new progress about Enantioselective synthesis. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dix, Stefan published the artcileRadical C-H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide, SDS of cas: 100-70-9, the main research area is trifluoromethoxylated hetero arene preparation; bis trifluoromethyl peroxide hetero arene radical CH trifluoromethoxylation photochem; (hetero)arenes; TEMPO; fluorine; photocatalysis; trifluoromethoxylation.

Herein, bis(trifluoromethyl)peroxide (BTMP, CF3OOCF3) as a practical and efficient trifluoromethoxylating reagent, which easily accessible from inexpensive bulk chems. was introduced. Using either visible light photoredox or TEMPO catalysis, trifluoromethoxylated arenes could be prepared in good yields under mild conditions directly from unactivated aromatics Moreover, TEMPO catalysis allowed for the one-step synthesis of valuable pyridine derivatives, which was previously prepared via multi-step approaches.

Chemistry – A European Journal published new progress about Photochemistry. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Karges, Johannes published the artcileSynthesis of tetranuclear rhenium(I) tricarbonyl metallacycles, Recommanded Product: Picolinonitrile, the main research area is tetranuclear rhenium tricarbonyl metallacycle preparation structure conformation; crystal structure mol tetranuclear rhenium tricarbonyl metallacycle preparation.

Re(I) tricarbonyl complexes have received much attention due to their attractive photochem., electrochem., and biol. properties. Beyond simple mononuclear complexes, multinuclear assemblies offer greater structural diversity and properties. Despite previous reports on the preparation of di-, tri-, or tetranuclear Re(I) tricarbonyl assemblies, the synthesis of these supramol. structures remains challenging due to overall low yields or tedious purification protocols. Herein, the facile preparation and characterization of tetranuclear Re(I) tricarbonyl metallacycles with a square geometry is reported using a tetrazole-based ligand. The synthesis of the metallacycle was optimized using different metal precursors, solvents, temperatures, and reagent concentrations Finally, the scope of suitable tetrazole-based ligands was explored to produce several tetranuclear Re(I) tricarbonyl-based metallacycles.

Dalton Transactions published new progress about Conformation. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Moghaddam, Firouz Matloubi published the artcileA ligand and Palladium-free Avenue for Cyanation of Aryl Halides: The Art of Samarium Powder in C-C Coupling Reaction, Computed Properties of 100-70-9, the main research area is benzonitrile preparation green chem chemoselective; aryl halide sodium cyanide cyanation samarium powder catalyst.

This was the first study of samarium powder catalyzed cyanation reaction of aryl halides, bearing electron-withdrawing and electron-releasing substituents, in the presence of NaCN to afford corresponding benzonitriles ArCN [Ar = C6H5, 4-O2NC6H4, naphth-1-yl, etc.] in high yields. This protocol took the advantage of being done in the absence of additive, ligand and precious transition metals such as palladium.

ChemistrySelect published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reilly, Sean W. published the artcileLate-Stage Carbon Isotope Exchange of Aryl Nitriles through Ni-Catalyzed C-CN Bond Activation, Quality Control of 100-70-9, the main research area is aryl nitrile zinc cyanide C13 nickel carbon isotope exchange; C13 aryl nitrile preparation.

A facile one-pot strategy for 13CN and 14CN exchange with aryl, heteroaryl, and alkenyl nitriles using a Ni phosphine catalyst and BPh3 is described. This late-stage carbon isotope exchange (CIE) strategy employs labeled Zn(CN)2 to facilitate enrichment using the nonlabeled parent compound as the starting material, eliminating de novo synthesis for precursor development. A broad substrate scope encompassing multiple pharmaceuticals is disclosed, including the preparation of [14C] belzutifan to illustrate the exceptional functional group tolerance and utility of this labeling approach. Preliminary exptl. and computational studies suggest the Lewis acid BPh3 is not critical for the oxidative addition step and instead plays a role in facilitating CN exchange on Ni. This CIE method dramatically reduces the synthetic steps and radioactive waste involved in preparation of 14C labeled tracers for clin. development.

Journal of the American Chemical Society published new progress about Bond activation (C-CN). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Delcaillau, Tristan published the artcileNickel-Catalyzed Reversible Functional Group Metathesis Between Aryl Nitriles And Aryl Thioethers, HPLC of Formula: 100-70-9, the main research area is aryl nitrile preparation; thioether aryl nitrile reversible functional group metathesis nickel catalyst; aromatic thioether preparation; nitrile aryl thioether reversible functional group metathesis nickel catalyst.

A new functional group metathesis between aryl nitriles and aryl thioethers via nickel/dcype catalysis to achieve fully reversible transformation to afford aryl nitriles R-CN [R = 4-tBuC6H4, 3-FC6H4, 2-naphthyl, etc.] and aryl thioethers R1-SMe [R1 = 4-NCC6H4, 2-pyridyl, 4-F3CC6H4, etc.] in good to excellent yields was reported. Furthermore, the cyanide and thiol-free reaction showed high functional-group tolerance and great efficiency for late-stage derivatization of com. mols. Finally, synthetic applications demonstrated its versatility and utility in multistep synthesis.

Journal of the American Chemical Society published new progress about Metathesis. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Banerjee, Indrani published the artcileEfficient and chemoselective hydroboration of organic nitriles promoted by TiIV catalyst supported by unsymmetrical acenaphthenequinonediimine ligand, Formula: C6H4N2, the main research area is titanium acenaphthenequinonediimine complex catalyst chemoselective hydroboration organic nitrile; crystal structure mol titanium acenaphthenequinonediimine complex preparation.

We report the synthesis, characterization, and utilization of a titanium (IV) complex [(η5-C5H5){L}TiCl2] (1) supported by a monoanionic ligand (L), N-(2, 6-diisopropyl)acenaphthenequinonediimido, as a mol. pre-catalyst for the hydroboration of nitriles. The unsym. N-silylated N-(2, 6-diisopropyl)-N-(trimethylsilyl)-acenaphthenequinonediimine ligand (LSiMe3) was obtained upon the completion of a one-pot reaction between N-(2, 6-diisopropyl)iminoacenaphthenone and lithium hexamethyldisilazide in the presence of trimethylsilyl chloride in 1:1:1 M ratio at 90 °C. The reaction of LSiMe3 with (η5-(C5H5)TiCl3) in equal proportion (1:1) at 60 °C afforded the titanium complex [(η5-C5H5){L}TiCl2] (1) in good yield. The mol. structures of the N-silyl ligand (LSiMe3) and Ti(IV) complex 1 were established by single-crystal X-ray anal. Complex 1 was tested as a pre-catalyst for hydroboration of nitriles with pinacolborane (HBpin) and catecholborane (HBcat) to afford diboryl amines at ambient temperature Titanium complex 1 exhibited high conversion, superior selectivity, and broad functional group tolerance during hydroboration of nitriles with both HBpin and HBcat under mild conditions.

Journal of Organometallic Chemistry published new progress about Boronic acids, esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

He, Dongxu published the artcileAsymmetric Transfer Hydrogenation of Densely Functionalized Diheteroaryl and Diaryl Ketones by a Ru-Catalyst of Minimal Stereogenicity, Product Details of C6H4N2, the main research area is ruthenium pyridinemethanamine phosphine complex preparation enantioselective transfer hydrogenation catalyst; heteroaryl aryl ketone enantioselective transfer hydrogenation ruthenium catalyst.

A highly enantioselective asym. transfer hydrogenation (ATH) of densely functionalized diheteroaryl and diaryl ketones was developed using ruthenium catalysts such as I of minimal stereogenicity. Various ketone substrates with structurally and electronically similar groups attached to the prochiral centers such as 2-pyridinyl 3-pyridinyl ketone were reduced successfully in good to excellent enantioselectivities and yields. This protocol provides practical and efficient access to chiral diheteroarylmethanols and benzhydrols, which are key intermediates in pharmaceuticals and biol. active compounds

Organic Letters published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dong, Sanfeng published the artcileOne step stereoselective synthesis of oxazoline-fused saccharides and their conversion into the corresponding 1,2-cis glycosylamines bearing various protected groups, COA of Formula: C6H4N2, the main research area is transition state glycosylamine oxazolinose benzonitrile aminoglycoside synthesis crystal structure.

Herein we disclosed a straightforward synthesis of oxazoline-fused saccharides (oxazolinoses) from peracetylated saccharides and benzonitriles under acidic conditions with stoichiometric amounts of water. The d. functional theory (DFT) calculations have revealed the origin of the stereoselectivity and the key role of water in promoting the departure of the acetyl group at C-2. The resulting oxazolinoses can be concisely converted into the corresponding 1,2-cis glycosylamines bearing various protected groups, allowing the access to schisandrin derivatives

Organic & Biomolecular Chemistry published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fukazawa, Yasuaki published the artcileA Mild Method for Electrochemical Reduction of Heterocyclic N-Oxides, Related Products of nitriles-buliding-blocks, the main research area is electrochem reduction heterocyclic amine oxide.

Deoxygenation of heteroaromatic N-oxides is commonly accomplished using chem. or enzymic methods. In this work, we report on an expedient protocol for electrochem. reduction of pyridine N-oxide derivatives under mild conditions. A diverse range of mono- and bis N-oxides were converted into the corresponding nitrogen bases in good yields. Importantly, the method is highly selective towards N-oxides and tolerates challenging halo and nitro substituents in the heteroaromatic ring. Thus, e.g., 2-phenylpyridine N-oxide �2-phenylpyridine (89% isolated) by carring out the reaction in an undivided electrochem. cell with two graphite electrodes in 1:1 MeCN/water mixture using LiBF4 as supporting electrolyte.

European Journal of Organic Chemistry published new progress about Chemoselectivity (of electroreduction of amine oxide function group in presence of halogen or nitro groups). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts