Adding a certain compound to certain chemical reactions, such as: 16532-79-9, name is 4-Bromophenylacetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16532-79-9, COA of Formula: C8H6BrN
4-bromophenylacetonitrile (23.0 g, 117 mmol) and iodine (29.8 g, 117 mmol) were dissolved in 400 ml of ether,Lower the temperature to -78 C. Sodium methoxide (13.3 g, 246 mmol) dissolved in anhydrous methanol at a concentration of 10 wt% is slowly dropped, the temperature is raised to 0 C, and the mixture is stirred for 4 hours. After the reaction was completed by adding 5% HCl (Hydrochloric acid) aqueous solution, the mixture was filtered, washed with water and cold methanol, and then recrystallized from chloroform and methanol to obtain a white solid .
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromophenylacetonitrile, and friends who are interested can also refer to it.
Reference:
Patent; LG Chemical Co., Ltd; Kim, Jin Suk; Choi, Chung-min; Bae, Jae-Sung; Lee, jae cheol; Lee, Ji Young; Jo, Geun; (30 pag.)KR101595147; (2016); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts