Zhou, Jingwei published the artcileCatalyst-free photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines, HPLC of Formula: 204078-32-0, the main research area is arylamine selective oxidative bond cleavage photochem catalyst free.
Due to the directional nature of sp3-hybridized orbitals and the absence of π-orbitals, the oxidative cleavage of the kinetically and thermodynamically stable C(sp3)-C(sp3) bond is extremely difficult and remains scarcely explored. In this work, under the double argument of quantum mechanics (QM) computations and meticulous experiments on authors’ well-designed C-C single bond cleavage mechanism, authors discovered a means of photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines, easily achieved by simple visible light irradiation using O2 as a benign oxidant under very mild conditions. The utility of methodol. was demonstrated by the C(sp3)-C(sp3) bond cleavage in morpholine/piperazine arylamines with excellent functional group tolerance. Importantly, this methodol. is noteworthy, not only it does not require any catalysts, but also it provides valuable possibilities for the scalable functionalization of clin. drugs and natural products.
Green Chemistry published new progress about C-C bond cleavage (photochem.). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, HPLC of Formula: 204078-32-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts