Lebedev, Yury published the artcileAsymmetric Hydroboration of Heteroaryl Ketones by Aluminum Catalysis, Recommanded Product: Picolinonitrile, the main research area is heterocyclic ketone enantioselective hydroboration aluminum catalyst; aluminum binol complex catalyst mechanism computational study.
A series of Me aluminum complexes bearing chiral biphenol-type ligands were found to be highly active catalysts in the asym. reduction of heterocyclic ketones (S/C = 100 – 500, ee up to 99%). The protocol is suitable for a wide range of substrates and has a high tolerance to functional groups. The formed 2-heterocyclic-alcs. are valuable building blocks in drug discovery or can be used as ligands in asym. catalysis. Isolation and comprehensive characterization of the reaction intermediates support a catalysis cycle proposed by DFT calculations
Journal of the American Chemical Society published new progress about Enantioselective synthesis. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts