Roy, Bivas Chandra published the artcileTandem synthesis of quinazolinone scaffolds from 2-aminobenzonitriles using aliphatic alcohol-water system, Category: nitriles-buliding-blocks, the main research area is aminobenzonitrile aliphatic alc water tandem hydration dehydrogenative coupling; quinazolinone preparation green chem.
Ru(II) complex catalyzed tandem synthesis of quinazolinone derivatives is reported here. In this sustainable protocol, 2-aminobenzonitriles were directly transformed to quinazolinones using alc.-water system. A variety of quinazolinones was successfully synthesized in good to excellent yields by utilizing challenging methanol and aliphatic alcs. The practical applicability of the protocol was extended by preparative scale synthesis of various heterocycles as well as natural products. To understand the mechanism of this protocol, several control experiments and DFT studies were carried out. Based on the DFT calculations, a metal-ligand cooperative mechanism was proposed for this system.
Catalysis Science & Technology published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (2-aminoaryl). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts