On June 14, 2012, Shi, Ce; Xiong, Zhengming; Chittepu, Padmaja; Aldrich, Courtney C.; Ohlfest, John R.; Ferguson, David M. published an article.Computed Properties of 5098-14-6 The title of the article was Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction. And the article contained the following:
Toll-like receptors (TLRs) are key targets in the design of immunomodulating agents for use as vaccine adjuvants and anticancer treatments. The imidazoquinolines, imiquimod and resiquimod, have been shown to activate TLR-7 and -8, which in turn induce cytokine production as part of the innate immune response. Herein, we report the synthesis and discovery of a C7-methoxycarbonyl derivative of imiquimod (5, I) that stimulates cytokine production but is devoid of TLR-7/8 activity. Data are presented that shows that this analog not only induces IL-12p40 and TNF production, similar to that of imiquimod and resiquimod, but greatly enhances the production of IL-1β, a key cytokine involved in the activation of CD4 T cells. It is further demonstrated that TLR-7/8 activation can be recovered by the addition of a C2-alkyl substituent to this newly discovered analog. The results support the existence of an alternative mechanism of action by which imidazoquinolines can stimulate cytokine production The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Computed Properties of 5098-14-6
The Article related to imidazoquinoline preparation toll like receptor cytokine sar, Pharmacology: Structure-Activity and other aspects.Computed Properties of 5098-14-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts