Reference of 179897-89-3,Some common heterocyclic compound, 179897-89-3, name is 5-Bromo-2-fluorobenzonitrile, molecular formula is C7H3BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 5-Bromo-2-fluoro-bcnzonitrile (1 0.05 g, 50.25 mmol) in DMSO (30mL) is addedsodiummetl1anethiolate (3.87 g, 55.27 mmol) portionwise at 0C. The reaction mixture is stirred for2h at r.t..Sodiummethanethiolate ( l.06g, 15.07 mmol) is added and stirred for further 2h at r.t ..The reaction mixture is diluted with water (1 00 mL) and the precipitate is filtered off and dried invacuo at 50C. Yield 88% m/z 228/230 [M+H]+, rt 1.26 min, LC-MS Method V018_S01.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-2-fluorobenzonitrile, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GRAUERT, Matthias; ANDERSKEWITZ, Ralf; GRUNDL, Marc; OOST, Thorsten; PAUTSCH, Alexander; PETERS, Stefan; WO2014/140081; (2014); A1;,
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