On March 15, 2019, Yeh, Li-Hsuan; Wang, Hung-Kai; Pallikonda, Gangaram; Ciou, Yu-Lun; Hsieh, Jen-Chieh published an article.Quality Control of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile The title of the article was Palladium-Catalyzed Dual Annulation: A Method for the Synthesis of Norneocryptolepine. And the article contained the following:
A novel procedure for the Pd-catalyzed dual annulation reaction of I and derivatives to synthesize the norneocryptolepine derivatives involving the concerted construction of two central heterocycles is reported. The further methylation of norneocryptolepine (II) to afford its alkaloid analog neocryptolepine implies that synthesis of various neocryptolepine derivatives is feasible. The oxidative addition of Pd(0) is indicated as the key step to activate the intramol. addition of nitrile according to the mechanism study. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Quality Control of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile
The Article related to norneocryptolepine synthesis dual annulation, Alkaloids: Alkaloids Containing Two Nitrogen Atoms and other aspects.Quality Control of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts