Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 939-79-7, name is 4-Methyl-3-nitrobenzonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 939-79-7
B. 4-Cyano-2-nitrobenzoic acid. To a 0 C. solution of 4-methyl-3-nitrobenzonitrile (5.0 g, 0.031 mol) in H2SO4 (83 mL) was added dropwise over 2 h a mixture of Na2Cr2O7 (14 g, 0.047 mol) and H2SO4 (15 mL). The reaction mixture was allowed to warm to room temperature with stirring over 48 h. The resulting green mixture was poured onto crushed ice, and the precipitate was collected by filtration. The filtered solids were dissolved in 5% aq. Na2CO3 (60 mL) and the residual solids were removed by filtration. The filtrate was treated with dilute HCl and the resulting precipitate was collected by filtration and dried in air to provide the title compound as a white solid (2.7 g, 46%). 1H NMR (500 MHz, CD3OD): 8.39 (d, J=1.3 Hz, 1H), 8.12 (dd, J=8.0, 1.3 Hz, 1H), 8.00 (d, J=8.0, 1H).
The synthetic route of 939-79-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Allison, Brett D.; Hack, Michael D.; Phuong, Victor K.; Rabinowitz, Michael H.; Rosen, Mark D.; US2005/38032; (2005); A1;,
Nitrile – Wikipedia,
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