Application of 326-62-5,Some common heterocyclic compound, 326-62-5, name is 2-(2-Fluorophenyl)acetonitrile, molecular formula is C8H6FN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Method B To the 2-fluorophenylacetonitrile (0.80 g, 5.92 mmol), benzyltriethyl-ammonium chloride (0.03 g, 0.12 mmol), and 1-bromo-2-chloroethane (1.70 g, 11.9 mmol) was added 50% aqueous NaOH (3.5 ml).. The reaction was stirred at 45 C. for 21 h and ethylene glycol was added (3 ml).. The reaction was then warmed to 100 C. and stirred for 7 h.. Upon cooling to RT, the reaction was diluted with water and washed with EtOAc. The aqueous layer was acidified to PH 2-3 with aqueous 6N HCl. The acidified solution was extracted with Et2O. The combined Et2O extracts were washed with water and brine and dried (MgSO4).. Filtration and evaporation of the solvent in vacuo afforded a pale yellow solid (1.06 g, 99%).. The arylcyclopropyl acid was coupled to the product of example 8, step 3, using the procedure of Example 8, step 4 to obtain 24B as the HCl salt. HRMS (M+H): found 532.2949.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(2-Fluorophenyl)acetonitrile, its application will become more common.
Reference:
Patent; Schering Corporation; US6391865; (2002); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts