On April 13, 2006, Ng, Raymond; Sui, Zhihua; Guan, Jihua; Lanter, James C.; Alford, Vernon C., Jr. published a patent.COA of Formula: C8H6F3N3 The title of the patent was Preparation of benzimidazole derivatives as selective androgen receptor modulators. And the patent contained the following:
Title compounds represented by the formula I [wherein R1 = H, alkyl, CH2-aryl, alkyl-OH, etc.; R2 = H, halo, (halo)alkyl, etc.; n = 0 or 1; R10 = H, halo, (halo)alkyl or OCOR8; R8 = (cyclo)alkyl, (hetero)aryl, aralkyl, etc.; R11 = H or halo; or R10and R11 are taken together with the carbon atom to which they are bound to form CO, C=N(OH) or C=N(O-alkyl); R12 = (halo)alkyl, alkyl-OH, CH2-aryl, etc.; and pharmaceutically acceptable salts thereof] were prepared as selective androgen receptor modulators (SARMS). For example, oxidation of 2-(5,6-dichloro-1-ethyl-1H-benzimidazol-2-yl)-1-ethanesulfanylpropan-2-ol by mCPBA gave II. II showed activity in ventral prostate and seminal vesicle weight in vivo assay and ventral prostate and levator ani weight in vivo assay. Thus, I and their pharmaceutical compositions are useful for the treatment of disorders and conditions modulated by the androgen receptor. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).COA of Formula: C8H6F3N3
The Article related to benzimidazole preparation selective androgen receptor modulator, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.COA of Formula: C8H6F3N3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts