On October 23, 2003, Shimojo, Masato; Taniguchi, Kana published a patent.Related Products of 34662-29-8 The title of the patent was Preparation of imidazoarenes as prostaglandin E2 subtype EP4 receptor antagonists for treatment of IL-6 involved diseases. And the patent contained the following:
The present invention relates to the use of a prostaglandin E2 (PGE2) subtype EP4 receptor ligand in the manufacture of a medicament for the treatment of interleukin 6 (IL-6) involved diseases, such as alc. cirrhosis, amyloidosis, atherosclerosis, cardiac disease, sclerosis, and organ transplantation reactions (no data). The invention also relates to the assay which comprises culturing peripheral whole blood with a test compound and determining the effect of the compound on PGE2-induced whole blood cells activation. Three hundred eighty title compounds I [wherein Y1-Y4 = N, CH, CL; R1 = H, (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, pyrrolidinyl, amino, etc.; A = (un)substituted 5-6 membered (un)substituted monocyclic (hetero)aromatic ring; B = halo-substituted alkylene, cycloalkylene, alkenylene, alkynylene, alkyleneoxy, etc., optionally substituted with an oxo or alkyl group; W = amino, O, S, bond, etc.; R2 = H, OH, alkyl, alkoxy; Z = 5-12 membered (un)substituted monocyclic or bicyclic (hetero)aryl; L = halo, alkyl, haloalkyl, OH, alkoxy, haloalkoxy, alkylthio, NO2, amino, etc.] were prepared Thus, cycloaddition of 2-[4-[(3-amino-4,6-dimethyl-2-pyridinyl)amino]phenyl]ethanol (4-step preparation given) with propionyl chloride in toluene provided 2-[4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethyl propionate, which was treated with aqueous LiOH to give the ethanol derivative (86%). Chlorination (90%) using thionyl chloride, conversion to the azide (85%), and Pd/C catalyzed hydrogenation afforded the amine (94%). Coupling of the amine with p-toluenesulfonyl isocyanate in CH2Cl2 gave II (56%). The latter significantly inhibited IL-6 secretion by PGE2 in ConA-stimulated human peripheral blood mononuclear cells (PBMC). The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Related Products of 34662-29-8
The Article related to imidazoarene preparation composition prostaglandin e2 ep4 antagonist, benzimidazole imidazopyridine preparation composition il6 disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Related Products of 34662-29-8
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts