On February 3, 2011, Shibata, Norio; Kagawa, Takumi published a patent.Category: nitriles-buliding-blocks The title of the patent was preparation of trifluoromethylthiophenium derivative salts as trifluoromethylating agents. And the patent contained the following:
Provided are trifluoromethylthiophenium derivative salts useful as intermediates in the synthesis of drugs or agricultural chems., a process for production of the same, and a process for the production of trifluoromethyl-containing compounds using the same as the trifluoromethylating agent. Specifically, S-(trifluoromethyl) -benzo[b]thiophenium derivative salts represented by general formula I [ R1-4 = H, C1-10 alkyl, C1-10 alkoxy, F, Cl, Br, NO2, CN; R5 = C1-10 alkyl, (substituted) phenyl; X = anion] is prepared by reacting trifluoromethyl 2-ethynylphenyl sulfide II with an acid. Thus, 2-cyclopropyl-1-trifluoromethylbenzo[b]thiophenium triflate was prepared by reacting 1-cyclopropylethynyl-2-trifluoromethylsulfanylbenzene with trifluoromethanesulfonic acid. When Me 1-indanone-2-carboxylate was treated with 2-cyclopropyl-1-trifluoromethylbenzo[b]thiophenium triflate, 1-oxo-2-trifluoromethylindan-2-carboxylic acid Me ester was obtained. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Category: nitriles-buliding-blocks
The Article related to trifluoromethylthiophenium derivative salt preparation trifluoromethylating agent, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenothiophenes and other aspects.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts