On January 17, 2022, Li, Chao; Wang, He; Liu, Lu; Sun, Ran; Wang, Xin; Zhou, Ming-Dong; Li, Lei published an article.COA of Formula: C9H5F3N2O2 The title of the article was Base-Catalyzed Intramolecular Self-Cyclization of o-Alkenylaryl Isocyanides: Access to 4-Cyano-3-arylquinolines. And the article contained the following:
A novel base-catalyzed intramol. self-cyclization reaction of o-alkenylaryl isocyanides [2-N+C–C6H3(R)-C(CN)(=CHR1)] (R = H, 3-Cl, 4-F, 5-Me, etc.; R1 = Ph, 4-chlorophenyl, 3,4-dimethylphenyl, 2-naphthyl, thiophen-2-yl, etc.) has been successfully developed. This reaction provides a general, efficient and atom-economic method to access 4-cyano-3-arylquinolines I (R2 = H, 8-Cl, 7-F, 6-Me, etc.) with broad scope of substrates and excellent functional group compatibilities. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).COA of Formula: C9H5F3N2O2
The Article related to aryl quinoline preparation, alkenylaryl isocyanide tandem heterocyclization cesium carbonate catalyst, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.COA of Formula: C9H5F3N2O2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts