On July 1, 2010, Li, Jianqi; Wang, Guan; Zhang, Guisen; Lv, Na; Jiao, Guangjun; Liu, Shicheng; Zhou, Shixia published a patent.Electric Literature of 34662-29-8 The title of the patent was Preparation of piperidinyl benzisoxazole derivatives as inhibitors of 5-HT2A receptor. And the patent contained the following:
The invention provides piperidinyl benzisoxazole derivatives with formula I [R = H, halo, (un)substituted alkyl, or alkoxy; X and Y independently = CH or N; Ra = H, halo, CN, (un)substituted alkyl, alkoxy, etc,], and their salts and hydrates, are prepared and disclosed. The invention compounds has antagonistic effect on 5-HT2A and has mediating effect on 5-hydroxytryptamine system such as reuptake inhibiting effect of 5-HT and so on. Thus, e.g., II was prepared by condensation reaction of N-(4-chlorobutyl)indole with 4-(6-fluorobenzisoxazol-3-yl)piperidine. II exhibited affinity to 5-HT2A with IC50 value of 1.659 nM and Ki value of 1.9806 nM. The compounds of the invention possess excellent analgesia, sedation activity, minimal toxicity and side effects. The invention also provides pharmaceutical compositions comprising the derivatives and their use. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Electric Literature of 34662-29-8
The Article related to benzisoxazole piperidinyl preparation 5hta receptor inhibitor pain, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Electric Literature of 34662-29-8
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts