On May 22, 2008, Ohlmeyer, Michael; Bohnstedt, Adolph; Kingsbury, Celia; Ho, Koc-Kan; Quintero, Jorge published a patent.Computed Properties of 138801-92-0 The title of the patent was Preparation of 7-substituted purine derivatives as immunosuppressants. And the patent contained the following:
Purinone derivatives of formula I [Q1, Q2 = (substituted) CH, N; Q3 = CH, N; R1-R3 = H, alkyl; R4 = alkyl, heterocyclyl, aryl, heteroaryl, etc.; R5 = alkyl, heterocyclyl, etc.; n = 0-3] are prepared for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. Thus, II was prepared, and inhibited IL-2 induced IFN-γ production by >40% at 30 mg/kg in mice. The experimental process involved the reaction of 4-Oxochroman-6-carbonitrile(cas: 138801-92-0).Computed Properties of 138801-92-0
The Article related to purinone derivative preparation immunosuppressant, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Computed Properties of 138801-92-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts