On October 14, 2004, Ando, Kazuo; Kawai, Makoto; Kawamura, Mitsuhiro; Matsumizu, Miyako; Morita, Asato; Sakurada, Isao published a patent.Reference of 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of heterocyclic bicyclic compounds as NR2B receptor antagonists. And the patent contained the following:
Title compounds I [R1-2 = H, halo, alkyl, alkoxy, etc.; X = bond, alkylene, etc.; A = bicyclic, aromatic, (un)saturated heterocyclic ring, etc.; B = Ph, heteroaryl, etc.] are prepared For instance, N-[(2-benzyl-1H-indol-5-yl)methyl]-4-hydroxybenzamide (II)is prepared in 2 steps from (2-benzyl-1H-indol-5-yl)carbonitrile. II has Ki = 2 nM for the NR2B receptor. I is useful for the treatment of disease conditions caused by over activation of NMDA NR2B receptor, e.g., pain. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Reference of 3-Chloro-4-nitrobenzonitrile
The Article related to bicyclic benzimidazole benzoxazole quinazoline nr2b receptor antagonist preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Two Hetero Atoms and other aspects.Reference of 3-Chloro-4-nitrobenzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts