On February 28, 2001, Belley, Michel; Scheigetz, John; Dube, Pascal; Dolman, Sarah published an article.Quality Control of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile The title of the article was Synthesis of N-aminoindole ureas from ethyl 1-amino-6-(trifluoromethyl)-1H-indole-3-carboxylate. And the article contained the following:
Two routes to the synthesis of Et 6-(trifluoromethyl)-1H-indole-3-carboxylate are described. N-Amination of this key intermediate with O-(diphenylphosphinyl)hydroxylamine and subsequent reactions with aryl isocyanates, using pyridine as solvent, gave 1-indolylureas in good yields. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Quality Control of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile
The Article related to indolylurea preparation, indolecarboxylate preparation isocyanate addition, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts