Belley, Michel; Sauer, Effiette; Beaudoin, Daniel; Duspara, Petar; Trimble, Laird A.; Dube, Pascal published an article in 2006, the title of the article was Synthesis and reactivity of N-hydroxy-2-aminoindoles.Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile And the article contains the following content:
Catalytic hydrogenation of (2-nitrophenyl)acetonitriles I (R1 = H, Cl, F, F3C, MeO, MeSO2, MeCONH; R2 = EtO2C, CN, MeSO2, PhSO2) bearing an electron-withdrawing substituent α to the nitrile, using Pd/C and (Ph3P)4Pd, affords N-hydroxy-2-aminoindoles II in good to excellent yields. (Ph3P)4Pd decreases the reduction rate of the intermediate hydroxylamine and acts as a catalyst during the cyclization onto the nitrile. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile
The Article related to acetonitrile nitrophenyl hydrogenation palladium catalyst, indole hydroxy amino preparation alkylation reduction acylation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts