On June 30, 2009, Li, Xun; Ng, Raymond A.; Zhang, Yongzheng; Russell, Ronald K.; Sui, Zhihua published an article.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile The title of the article was An efficient synthetic process for scale-up production of 4,5-diamino-2-(trifluoromethyl)benzonitrile and 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine. And the article contained the following:
Starting from 4-amino-2-(trifluoromethyl)benzonitrile, an efficient and nonchromatog. process was developed for multihundred gram production of 4,5-diamino-2-(trifluoromethyl)benzonitrile in 73% yield and 98 HPLC area% purity over four synthetic steps. The same synthetic strategy was applied to 4-bromo-2-(trifluoromethyl)aniline that afforded 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine in 81% overall yield and 99% HPLC area% purity. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile
The Article related to fluoromethyldiaminobenzonitrile production, bromotrifluoromethylbenzenediamine production, amination aniline fluoromethyl derivative, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts