On July 6, 1988, Matsuo, Masaaki; Tsuji, Kiyoshi; Konishi, Nobukiyo published a patent.Recommanded Product: 34662-29-8 The title of the patent was Phenoxy-substituted alkanesulfonanilide derivatives useful as analgesics, antiinflammatories, and antipyretics, and processess for their preparation. And the patent contained the following:
Title derivatives I [R1, R2, R8 = H, cyano, halo, alkyl, haloalkyl, alkythio, -sulfinyl, -sulfonyl, alkoxy; R3 = alkyl, mono- or dialkylamino; R4 = acyl, cyano, CO2H, hydroxyalkyl, SH, alkylthio, -sulfinyl, -sulfonyl, 2-oxodioxolan-3-ylidenemethyl, CR6:NR7, (un)substituted 5-membered unsaturated heterocyclyl; SPh; R5 = H, halo, alkoxy, carboxyalkoxy, alkoxycarbonylalkoxy, ureido, thiouredo] are prepared for use as analgesics, antiinflammatories, and antipyretics. 4-Amino-3-(2,4-difluorophenoxy)acetophenone was prepared in 4 steps and sulfonylated by MeSO2Cl in pyridine to give acetyl(difluorophenoxy)methanesulfonanilide II. In the adjuvant arthritis test in rats, II at 1.0 mg/kg/day orally inhibited secondary (uninjected) paw lesion by 50%, vs. only 24.7% by ibuprofen at 10.0 mg/kg. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 34662-29-8
The Article related to phenoxyalkanesulfonanilide preparation analgesic antiinflammatory antipyretic, alkanesulfonanilide phenoxy preparation analgesic antiinflammatory, sulfonanilide phenoxyalkane preparation analgesic antiinflammatory and other aspects.Recommanded Product: 34662-29-8
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts