Nitriles used to be known as cyanides; the smallest organic nitrile is ethanenitrile, CH3CN, (old name: methyl cyanide or acetonitrile – and sometimes now called ethanonitrile). 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds, including methyl cyanoacrylate, used in super glue, and nitrile rubber, a nitrile-containing polymer used in latex-free laboratory and medical gloves. Computed Properties of 105-34-0.
Xu, Hui;Weng, Ming-Yue;Chen, Hong;Zhang, Ze research published 《 Unexpected Iodine-Promoted Aerobic Oxidation of α-Cyano-δ-keto Esters: A Facile Synthesis of α,δ-Dicarbonyl Esters》, the research content is summarized as follows. An efficient and green method for the synthesis of various α,δ-dicarbonyl esters R1C(O)CH2CH(R2)C(O)C(O)OR3 (R1 = Me, Ph, 2-naphthyl, 2-furanyl, etc.; R2 = Ph, 3-methylphenyl, 2,4-dichlorophenyl, etc.; R3 = Me, Et) has been developed via a conjugate addition of ethyl/methyl cyanoacetate to chalcones R1C(O)CH=CHR2 and subsequent iodine-promoted aerobic oxidation The present protocol features mild reaction conditions, high efficiency, easily available starting materials, and broad substrate scope.
Computed Properties of 105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., 105-34-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts