Nitriles are found in many useful compounds. Nitrile rubber is also widely used as automotive and other seals since it is resistant to fuels and oils. Organic compounds containing multiple nitrile groups are known as cyanocarbons. 105-34-0, formula is C4H5NO2, Name is Methyl 2-cyanoacetate. Nitriles are found in many useful compounds. One of the most common occurrences of nitriles is in Nitrile rubber. Electric Literature of 105-34-0.
Lusardi, Matteo;Rotolo, Chiara;Ponassi, Marco;Iervasi, Erika;Rosano, Camillo;Spallarossa, Andrea research published 《 One-Pot Synthesis and Antiproliferative Activity of Highly Functionalized Pyrazole Derivatives》, the research content is summarized as follows. A series of highly functionalized pyrazole derivatives was prepared by a one-pot, versatile and regioselective procedure. Pyrazoles I [R = C6H11, Bn, 3-O2NC6H4, etc.; X = CN, H2NCO, MeO2S, etc.; Y’ = Me, NH2, Ph, etc.; XY’ = OCCH2C(CH3)2CH2] were tested in cell-based assay to assess their antiproliferative activity against a panel of tumor cells. Addnly., the cytotoxicity of prepared compounds I was evaluated against normal human fibroblasts. The antiproliferative activity of the synthesized mols. affected by the nature of the substituents of the pyrazole scaffold and derivatives I [R = C6H11, Bn, Ph; X = CO2Me; Y = NH2] proved to inhibited the growth of melanoma and cervical cancer cells. Compound I [R = Ph; X = CO2Me; Y = NH2] was identified as the most active derivative and docking simulations predicted its ability to interact with estrogen receptors.
105-34-0, Methyl cyanoacetate is an alkyl cyanoacetate ester.
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knövenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α -cyanocinnamic esters.
Methyl Cyanoacetate is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate (M287290); a compound used in the synthesis of DPP-IV inhibitors for treating type 2 diabetes., Electric Literature of 105-34-0
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts