On October 1, 2007, Carreiras, M. Carmo; Eleuterio, Ana; Dias, Catarina; Brito, M. Alexandra; Brites, Dora; Marco-Contelles, J.; Gomez-Sanchez, Elena published an article.Electric Literature of 5098-14-6 The title of the article was Synthesis and Friedlander reactions of 5-amino-4-cyano-1,3-oxazoles. And the article contained the following:
The synthesis of a series of 2-substituted 5-amino-4-cyano-1,3-oxazoles and the Friedlander-type reaction of some of them with cyclic ketones was described. Oxazolo[5,4-b]quinoline derivatives were tacrine analogs provided by the Friedlander reaction. Their anticholinesterase activity has been investigated and the compound I was found to be the most active (60% inhibition), at the maximum soluble concentration The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Electric Literature of 5098-14-6
The Article related to aryl acid chloride chloride aminomalonitrile tosylate heterocyclization, alkyl acid chloride aminomalonitrile tosylate heterocyclization, amino cyanooxazole derivative preparation cycloalkanone friedlander cyclization aluminum chloride and other aspects.Electric Literature of 5098-14-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts