On December 31, 2014, Dyachenko, I. V.; Ramazanova, E. Yu.; Dyachenko, V. D. published an article.Category: nitriles-buliding-blocks The title of the article was Synthesis of 4-methylmorpholinium 6-amino-3,5-dicyano-4-(furan-2-yl)pyridine-2-thio(seleno)lates and 3-[aryl(hetaryl)]-2-cyanoprop-2-enethioamides by michael reaction. And the article contained the following:
Michael reaction of di-Me (furan-2-ylmethylidene)malonate with 2-cyanoethanethio(seleno)amides and 4-methylmorpholine afforded 4-methylmorpholinium 6-amino-3,5-dicyano-4-(furan-2-yl)pyridine-2-thio(seleno)lates (I.4-methylmorpholinium; X = S, Se) via exchange of the CH acid components. Aryl(hetaryl)methylidenemalononitriles II reacted with cyanoethanethioamide under analogous conditions to give 3-aryl(hetaryl)-2-cyanoprop-2-enethioamides III which were converted into 3-aryl(hetaryl)-2-(1,3-thiazol-2-yl)prop-2-enenitriles (IV) according to Hantzsch (using BrCH2COR’, R’ = e.g., Ph). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Category: nitriles-buliding-blocks
The Article related to michael carbon acid exchange furanylmethylenemalonate arylmethylenemalononitrile cyanoethanethioamide cyanoethaneselenoamide, pyridinethiolate aminocyanofuranyl, pyridineselenolate aminocyanofuranyl, hantzsch thiazole synthesis arylcyanopropenethioamide and other aspects.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts