On May 1, 2004, Marco, Jose L.; de los Rios, Cristobal; Garcia, Antonio G.; Villarroya, Mercedes; Carreiras, M. Carmo; Martins, Carla; Eleuterio, Ana; Morreale, Antonio; Orozco, M.; Luque, F. Javier published an article.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was Synthesis, biological evaluation and molecular modelling of diversely functionalized heterocyclic derivatives as inhibitors of acetylcholinesterase/butyrylcholinesterase and modulators of Ca2+ channels and nicotinic receptors. And the article contained the following:
The synthesis and the biol. activity of heterocyclic derivatives as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as modulators of voltage-dependent Ca2+ channels and nicotinic receptors, are described. These mols. are tacrine analogs, which have been prepared from polyfunctionalized 6-amino-5-cyano-4H-pyrans, 6-amino-5-cyano-pyridines and 5-amino-2-aryl-3-cyano-1,3-oxazoles via Friedlander reaction with selected cycloalkanones. These compounds are moderate acetylcholinesterase and butyrylcholinesterase inhibitors, the BuChE/AChE selectivity of the most active mols. ranges from 10.0 to 76.9. Interestingly, the oxazolo-tacrine’ derivatives are devoid of any activity. All compounds showed an important inhibitory effect on the nicotinic acetylcholine receptor. Most of them also blocked L-type Ca2+ channels, and three of them blocked the non-L type of Ca2+ channels. Mol. modeling studies suggest that these compounds might bind at the peripheral binding site of AChE, which opens the possibility to design inhibitors able to bind at both, the catalytic and peripheral binding sites of the enzyme. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate
The Article related to heterocyclic derivative preparation acetylcholinesterase butyrylcholinesterase inhibitor, calcium channel modulator heterocyclic derivative, nicotinic receptor inhibitor heterocyclic derivative, tacrine analog preparation acetylcholinesterase butyrylcholinesterase inhibitor and other aspects.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts