On July 25, 2022, Zhu, Lixiang; Peng, Heling; Guo, Yan; Che, Jixing; Wu, Jia-Hong; Su, Zhishan; Wang, Tianli published an article.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Enantioselective Synthesis of Atropisomeric Biaryl Phosphorus Compounds by Chiral-Phosphonium-Salt-Enabled Cascade Arene Formation. And the article contained the following:
Axially chiral biaryl monophosphorus mols., exemplified by atropisomeric 1,1′-biaryl aminophosphines, are significant motifs in numerous chiral ligands/catalysts. Developing efficient methods for preparing P compounds with these privileged motifs is an important endeavor in synthetic chem. Herein, the authors develop an effective, modular method by a chiral-phosphonium-salt-catalyzed novel cascade between P-containing nitroolefins and α,α-dicyanoolefins, leading to a great diversity of atropisomeric biaryls bearing P groups in high yields with excellent stereoselectivities. The reaction features include a Thorpe-type cycloaddition/oxidative hydroxylation/aromatization cascade pathway with a central-to-axial chirality transfer process. Insight gained from the authors’ studies is expected to advance general efforts towards the catalytic synthesis of atropisomeric biaryl P compounds, offering a platform for developing new efficient chiral ligands and catalysts. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile
The Article related to naphthyl nitroolefin cycloaddition cyanoolefin chiral phosphonium salt catalyst, aminophosphorylnaphthalenylnitro dihydrophenanthrene carbonitrile derivative preparation crystal structure, mol structure aminophosphorylnaphthalenylnitro dihydrophenanthrene carbonitrile derivative, atropisomerism, biaryl phosphines and other aspects.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts