Groth, Ulrich; Huhn, Thomas; Kesenheimer, Christian; Kalogerakis, Aris published an article in Synlett. The title of the article was 《Cobalt-mediated regioselective synthesis of substituted tetrahydroquinolines》.Application In Synthesis of 2-(4-Bromo-3-indolyl)acetonitrile The author mentioned the following in the article:
A regioselective synthesis of polycyclic substituted pyridines, e.g., I, is reported. Key step was the cobalt-catalyzed intramol. cyclization of diynenitriles, tethered by a silicon oxygen bond. Subsequent opening of the Si-O ring led then to the related tetrahydroquinolines. The results came from multiple reactions, including the reaction of 2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2Application In Synthesis of 2-(4-Bromo-3-indolyl)acetonitrile)
2-(4-Bromo-3-indolyl)acetonitrile(cas: 89245-35-2) is a member of nitriles. Nitriles have been reduced to amines by many methods, especially by catalytic hydrogenation and by metal hydrides. Aliphatic and aromatic nitriles have also been reduced to nitro derivatives using hydrazinium monoformate in the presence of Raney-nickel.Application In Synthesis of 2-(4-Bromo-3-indolyl)acetonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts