Computed Properties of C9H7NOIn 2022 ,《Efficient synthesis of novel spiro[indoline-3,5′-pyrano-[2,3-d]pyrimidin]-2-one derivatives and antitumor activity evaluation》 was published in Heterocycles. The article was written by Li, Zhenhua; Huang, Guoqing; Rong, Dayou; Cao, Yingyan; Hu, Ronghui. The article contains the following contents:
An efficient method for synthesis of the spiro[indoline-3,5′-pyrano[2,3-d]pyrimidin]-2-one derivatives I [R1 = H, 7-Me, 5-Cl, etc.; R2 = H, Me; R3 = CN, C(O)Me, CO2Et; R4 = Me, Ph] from 2′-amino-2-oxospiro[indoline-3,4;-pyran]-3′-carbonitriles using bis(trichloromethyl) carbonate (BTC) and triphenylphosphine oxide (TPPO) was developed. A series of target compounds I with broad substrate scope were synthesized in moderate to good yields. Some of the compounds I were evaluated for antitumor activities against four cancer cell lines A549, HepG-2, MCF-7 and HeLa using 5-FU and cisplatin as reference and showed good antitumor activity when compared with the standard drugs. In addition to this study using 3-Oxo-3-phenylpropanenitrile, there are many other studies that have used 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Computed Properties of C9H7NO) was used in this study.
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used in the synthesis of substituted naphtho[1,8-bc]pyrans. It was also used as building block in the preparation of 4H-pyrans, 2-pyridones, furans and carbocyclics.Computed Properties of C9H7NO
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts