《Transition-metal-free, meta-selective arene CH direct α-aryl cyanomethylation of naphthalimide using a trifluoromethyl directing group》 was published in Dyes and Pigments in 2020. These research results belong to Li, Zheyao; Rao, Caihui; Chen, Lu; Fu, Chao; Zhu, Tingting; Chen, Xi; Liu, Chuanxiang. Safety of 2-(3-Bromophenyl)acetonitrile The article mentions the following:
A method for introducing a substituted aryl acetonitrile group at the C2 position of naphthalimide using trifluoromethyl as the directing group was reported. The transformation was operationally simple, requires mild conditions and was highly regioselective, without the need for a transition metal catalyst. This work provided a novel route for preparing α-diaryl nitrile derivatives I [R = Ph, 3-BrC6H4, 4-MeOC6H4, etc.]. After reading the article, we found that the author used 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5Safety of 2-(3-Bromophenyl)acetonitrile)
According to other reports, 2-(3-Bromophenyl)acetonitrile(cas: 31938-07-5) is used in the preparation of diarylpyrimidines (DAPYs) as HIV-1 non-nucleoside reverse transcriptase inhibitors.Safety of 2-(3-Bromophenyl)acetonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts