In 2019,Chemical Science included an article by Song, Hualong; Rogers, Nicola J.; Allison, Simon J.; Brabec, Viktor; Bridgewater, Hannah; Kostrhunova, Hana; Markova, Lenka; Phillips, Roger M.; Pinder, Emma C.; Shepherd, Samantha L.; Young, Lawrence S.; Zajac, Juraj; Scott, Peter. Electric Literature of C8H6BrN. The article was titled 《Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification》. The information in the text is summarized as follows:
Helicates and related metallofoldamers, synthesized by dynamic self-assembly, represent an area of chem. space inaccessible by traditional organic synthesis, and yet with potential for discovery of new classes of drug. Here we report that water-soluble, optically pure Fe(II)- and even Zn(II)-based triplex metallohelices are an excellent platform for post-assembly click reactions. By these means, the in vitro anticancer activity and most importantly the selectivity of a triplex metallohelix Fe(II) system are dramatically improved. For one compound, a remarkable array of mechanistic and pharmacol. behaviors is discovered: inhibition of Na+/K+ ATPase with potency comparable to the drug ouabain, antimetastatic properties (including inhibition of cell migration, re-adhesion and invasion), cancer stem cell targeting, and finally colonosphere inhibition competitive with the drug salinomycin. In the experimental materials used by the author, we found 4-Cyanobenzyl bromide(cas: 17201-43-3Electric Literature of C8H6BrN)
4-Cyanobenzyl bromide(cas: 17201-43-3) is used in the synthesis of ligands containing a chelating pyrazolyl-pyridine group with a pendant aromatic nitrile. It is also useful in the preparation of 4-[(2H-tetra-zol-2-yl)methyl]benzonitrile by reaction with 2H-tetrazole in the presence of potassium hydroxide.Electric Literature of C8H6BrN
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts