Adding a certain compound to certain chemical reactions, such as: 19924-43-7, name is 2-(3-Methoxyphenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19924-43-7, category: nitriles-buliding-blocks
Production of l-(3- methoxyphenyl ) cyclopropanecarbonitrile60% Sodium hydride (2.72 g) was suspended in N, N- dimethylformamide (80 mL) and the mixture was cooled to00C. A solution of ( 3-methoxyphenyl) acetonitrile (4.00 g) in N, N-dimethylformamide (20 mL) was added dropwise to the mixture and the mixture was stirred at 00C for 1 hr. 1 , 2-Dibromoethane (3.5 mL) was added dropwise to the reaction mixture, and the mixture was stirred at room temperature for 17 hr. A saturated aqueous ammonium chloride solution was added to the reaction mixture, and the mixture was extracted with diethyl ether. The organic layer was washed successively with water and saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was separated and purified by silica gel column chromatography (hexane : ethyl acetate=100 : 0-?80 : 20 ) to give the title compound (2.76 g) as a yellow oil.1H-NMR (CDCl3) delta: 1.36-1.44 (2H, m) , 1.67-1.75 (2H, m) , 3.81 (3H, s), 6.77-6.89 (3H, m) , 7.21-7.29 (IH, m)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(3-Methoxyphenyl)acetonitrile, and friends who are interested can also refer to it.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/64045; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts