In 2019,ChemistrySelect included an article by Vaarla, Krishnaiah; Karnewar, Santosh; Panuganti, Devayani; Peddi, Saikiran Reddy; Vedula, Rajeswar Rao; Manga, Vijjulatha; Kotamraju, Srigiridhar. Product Details of 614-16-4. The article was titled 《3-(2-(5-Amino-3-aryl-1H-pyrazol-1-yl)thiazol-4-yl)-2H-chromen-2-ones as Potential Anticancer Agents: Synthesis, Anticancer Activity Evaluation and Molecular Docking Studies》. The information in the text is summarized as follows:
In an effort to design and develop efficient anticancer agents here, the synthesis, anticancer activity and mol. docking studies of new 3-(2-(5 amino-3-aryl-1H-pyrazol-1-yl)thiazol-4-yl)-2H-chromen-2-ones I (R = H, Cl, OCH3 etc.; R1 = H, Cl, Br, etc.; R2 = H, Br, C6H5) is reported. The target products were synthesized via a facile one pot multicomponent approach by utilizing various substituted 3-(2-bromoacetyl)coumarins, thiosemicarbazide and benzoylacetonitriles with excellent yields. All the synthesized compounds were screened for their anticancer activity against five human cancer cell lines [L1210, CEM, DU-145, HeLa, and MCF-7]. Among the tested compounds, 6-diethylamino substituted compound I (R = R2 = H; R1 = N(CH2CH3)2) exhibited excellent potency against tested cancer cell lines, whereas 6,8-ditert-Bu substituted compound I (R = R1 = C(CH3)3; R2 = H) showed promising activity against DU-145 and MCF-7 cancer cell lines with IC50 values of 7 +/- 1 and 9 +/- 6 μM. Mol. docking study was carried out in order to understand the most plausible binding site interactions of the compounds with human Epidermal growth factor receptor (EGFR). In the experiment, the researchers used many compounds, for example, 3-Oxo-3-phenylpropanenitrile(cas: 614-16-4Product Details of 614-16-4)
3-Oxo-3-phenylpropanenitrile(cas: 614-16-4) has been used to produce 2-benzoyl-3-furan-2-yl-acrylonitrile. It is an active methylene compound, useful in heterocyclic synthesis, e.g. polyfunctional pyridines and pyrimidines.Product Details of 614-16-4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts